Patterns of cyclin A and B1 immunostaining in papillary thyroid carcinoma
Journal Title: Annals of Agricultural and Environmental Medicine - Year 2015, Vol 22, Issue 4
Abstract
[b]Introduction and objectives. [/b]Cyclin A, encoded by CCNA (cyclin A) gene with locus in chromosome 4q27, and cyclin B1, encoded by CCNB1 (cyclin B1) gene with locus in chromosome 5q12, are proteins that play a key role in the passage through the restriction point in G2 phase of the cell cycle. The aim of the study was to analyse immunohistochemically the expression of cyclins A and B1 in different variants of papillary thyroid carcinoma (PTC). [b]Material and methods[/b]. The immunostaining patterns of the proteins in question in the tissue of 40 resected PTC (20 cases of classic variant of PTC, 9 cases of PTC follicular variant and 11 cases of other non-classic variants of PTC) were investigated. [b]Results.[/b] On analyzing cyclin A and B1 expression, positive staining in 90% cases of PTC were observed. The study revealed a significant difference in expression of cyclins A and B1 between classic and non-classic variants of PTC. The expression of both examined cyclins was weaker in the classic variant of PTC. In the group of follicular variant of PTC, the expression of cyclins was of medium intensity and in the group of other non-classic variants of PTC, the expression was clearly higher. [b]Conclusions. [/b]The results of the presented study suggest that cyclins A and B1 expression may have a characteristic pattern of immunostaining for particular variants of PTC. If the obtained results are confirmed in a larger group of patients, the diagnostic panel constructed of the antibodies against these proteins may increase the diagnostic accuracy in PTC cases.
Authors and Affiliations
Anna Cyniak-Magierska, Magdalena Stasiak, Maciej Naze, Marek Dedecjus, Jan Brzeziński, Andrzej Lewiński
Keywords
Related Articles
- EP ID EP81048
- DOI -
- Views 162
- Downloads 0
Diabetes and depression: a combination of civilization and life-style diseases is more than simple problem adding – literature review
The article presents a review of current medical and psychological literature published between 2000 - 2010, with the use of the PubMed database, concerning the occurrence of anxiety and depression in diabetic patients,...
Health impact of wind farms
[b]Introduction and objective:[/b] Wind power is employed worldwide as an alternative source of energy. At the same time, however, the health effects of wind turbines have become a matter of discussion. The purpose of th...
Unusual presentation of the urogenital myiasis caused by Luciliasericata (Diptera: Calliphoridae)
Introduction and objective. The case report describes the unusual presentation of the urogenital myiasis caused by [i]Luciliasericata[/i] in two Slovakian men.Material and methods: The first patient, aged 66, who suffere...
Bioimpedance vector pattern in women with breast cancer detected by bioelectric impedance vector analysis. Preliminary observations
Introduction and objectives: The study was conducted to evaluate soft tissue hydration and mass through pattern analysis of vector plots as height, normalized resistance, and reactance measurements by bioelectric impedan...
Detection of [i]CHLAMYDIA PSITTACI[/i] in feral pigeons ([i]COLUMBA LIVIA DOMESTICA[/i]) in Slovakia and their characterisation
[b]Introduction and objectives.[/b] [i]Chlamydia psittaci[/i], an obligate intracellular bacterium, which is the etiologic agent of avian chlamydiosis in birds and ornithosis/psittacosis in humans, has been reported to b...