Patterns of cyclin A and B1 immunostaining in papillary thyroid carcinoma
Journal Title: Annals of Agricultural and Environmental Medicine - Year 2015, Vol 22, Issue 4
Abstract
[b]Introduction and objectives. [/b]Cyclin A, encoded by CCNA (cyclin A) gene with locus in chromosome 4q27, and cyclin B1, encoded by CCNB1 (cyclin B1) gene with locus in chromosome 5q12, are proteins that play a key role in the passage through the restriction point in G2 phase of the cell cycle. The aim of the study was to analyse immunohistochemically the expression of cyclins A and B1 in different variants of papillary thyroid carcinoma (PTC). [b]Material and methods[/b]. The immunostaining patterns of the proteins in question in the tissue of 40 resected PTC (20 cases of classic variant of PTC, 9 cases of PTC follicular variant and 11 cases of other non-classic variants of PTC) were investigated. [b]Results.[/b] On analyzing cyclin A and B1 expression, positive staining in 90% cases of PTC were observed. The study revealed a significant difference in expression of cyclins A and B1 between classic and non-classic variants of PTC. The expression of both examined cyclins was weaker in the classic variant of PTC. In the group of follicular variant of PTC, the expression of cyclins was of medium intensity and in the group of other non-classic variants of PTC, the expression was clearly higher. [b]Conclusions. [/b]The results of the presented study suggest that cyclins A and B1 expression may have a characteristic pattern of immunostaining for particular variants of PTC. If the obtained results are confirmed in a larger group of patients, the diagnostic panel constructed of the antibodies against these proteins may increase the diagnostic accuracy in PTC cases.
Authors and Affiliations
Anna Cyniak-Magierska, Magdalena Stasiak, Maciej Naze, Marek Dedecjus, Jan Brzeziński, Andrzej Lewiński
Keywords
Related Articles
- EP ID EP81048
- DOI -
- Views 141
- Downloads 0
Drinking of chokeberry juice from the ecological farm Dzieciolowo and distensibility of brachial artery in men with mild hypercholesterolemia.
The aim of the study was to estimate the influence of drinking chokeberry juice on the endothelial function in men with mild hypercholesterolemia. It was shown that chronic treatment with flavonoids improves vascular fun...
Air-borne dermatitis from [i]Chrysanthemum[/i] – case report with a discussion of diagnostic procedures and therapy
Airborne dermatitis belongs to a heterogeneous group of dermatoses of various etiopathology and clinical characteristics. This disease is characterized by acute or chronic inflammation of the uncovered skin exposed to ir...
Redukcja ochratoksyny A przez probiotyk w paszy dla drobiu.
Mikotoksyny obecne w paszach mogą wywołać problemy zdrowotne u ludzi i zwierząt. Dane opublikowane przez FAO w 2001 pokazują, że 25% z światowych plonów jest zanieczyszczona mikotoksynami, a ich rodzaj i stężenie są w du...
New cases of suspected HFRS (Hantavirus infection) in south-eastern Poland
Introduction: HFRS – hemorrhagic fever with renal syndrome, found in Europe, is an acute viral zoonosis due to the hantavirus infection. The disease is characterized by the triad of symptoms: sudden, febrile onset, acute...
Cancer risk factors in Poland: the PONS Study
Introduction: The burden of cancer in Eastern Europe is expected to increase, and in 2006, Polish males were ranked second in lifetime risk of lung cancer. The Polish-Norwegian Study (PONS) is a population study in the K...