Patterns of Restricted Diffusion within Corpus Callosum in Neonatal Hypoxic-Ischemic Encephalopathy and its Significance in Predicting the Clinical Outcome
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2018, Vol 6, Issue 7
Abstract
Background: Hypoxic-ischemic encephalopathy (HIE) continues to be a dreadful cause of morbidity and mortality in neonates and is a leading cause of cerebral palsy and other neurodevelopmental deficits. It manifests in different patterns of brain involvement on magnetic resonance imaging (MRI), of which restricted diffusion within the splenium, genu, or body of the corpus callosum has received less attention in the literature. In this review, we will describe a series of cases showing this pattern of injury. Materials and Methods: MRI including diffusion-weighted imaging was performed in 28 neonates with known or clinically suspected HIE, including both premature and term neonates. Results: 11 out of 28 patients demonstrated restricted diffusion in the corpus callosum. Out of these 11 patients, 6 showed restricted diffusion in the entire corpus callosum, 3 showed isolated splenium involvement, 1 had body and splenium signal abnormality, and 1 showed diffusion restriction in the genu and splenium. Aims: The aim is (1) to study the patterns of restricted diffusion in corpus callosum in neonatal HIE and (2) to demonstrate that corpus callosum involvement is associated with extensive brain insult. Conclusions: Cytotoxic lesions of the corpus callosum in neonate with HIE are associated with extensive brain injury and emerges to be an early neuroradiologic marker of adverse outcome. Splenium of corpus callosum is the most vulnerable location for ischemic injury. Corpus callosal injury is more common among term than preterm neonates.
Authors and Affiliations
Alle Praveen Kumar, Nadeem Ahmed, Uzma Afreen
Keywords
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