Peculiarities of microbic landscape at NSAID-induced gastropathy in patients with diabetes mellitus

Journal Title: Сучасна гастроентерологія - Year 2018, Vol 0, Issue 3

Abstract

Objective — to investigate the frequency and nature of microbial lesions of the mucous membrane of the upper gastrointestinal tract in patients with NSAID-induced gastropathy against the background of diabetes mellitus (DM). Materials and methods. The study involved 108 patients with NSAID-induced gastropathy (48 % men, n = 52; 53 % women, n = 56), who were in- or outpatients of the clinic of the Kharkiv National Medical University. The mean age was 42.5 ± 4.5 years. The main group consisted of 51 (47 %) DM patients, the comparison group included 57 (53 %) patients without DM. Both groups were age- and gender-matched. The microbiological study (including Helicobacter and fungal infection) of the material (obtained during EGDS (biopsy) from the stomach antrum and/or zones around the ulcer was carried out; the fungi and bacterial sensibility to chemotherapeutic agents was determined. Results. The patients with H. pylori-associated gastropathies significantly prevailed in the main group (р < 0.05). In 70 (64.2 %) examined patients the microbial composition was characterized by the predominance of combinations of bacteria and Candida fungi. Biofilms were found in all patients of the main group. At defects greater than 1.0 cm, probability of joining of the fungal infection increased (OR 7.0, 95 % CI 2.67 — 18.33; р < 0.0001). Investigation of sensibility of the obtained biofilms to the effects of chemotherapeutic agents showed that amphotericin B and nystatin had greatest antimycotic activity. The types of bacteria obtained from patients were more sensitive to cephalosporin antibiotics and azithromycin. Conclusions. In patients with NSAID-induced gastropathy against the background of diabetes mellitus the risk of contamination of the mucous membrane of the upper parts of gastrointestinal tract by associations of bacteria and fungi reliably rises. Biofilms provoke an increased resistance of microorganisms to antifungal drugs and antibiotics. In patients with diabetes mellitus, the targeted research on dysbiosis in the upper parts of gastrointestinal mucosa should be performed. The determination of the chemosensitivity of each of the obtained microorganisms is also required.

Authors and Affiliations

L. M. Bobro, T. V. Golovko

Keywords

Related Articles

The role of serum biomarkers in the diagnosis of nonalcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD) is a disease characterized by liver steatosis and the ability to progress to more serious pathological conditions, including non-alcoholic steatohepatitis (NASH), fibrosis and ci...

Intestinal microbiota in liver diseases: current state of the problem

The article presents analysis of the recent literature data, the results of experimental and clinical studies on role of participation the intestinal microbiota in the pathogenesis of various liver diseases: viral hepati...

The relationship of serum inflammatory markers with metabolic disorders at the non-alcoholic fatty liver disease

Objective — to study the serum levels of proinflammatory markers and determine their role in the formation of metabolic disorders in patients with non-alcoholic fatty liver disease (NAFLD). Materials and methods. Examin...

Vegetative accompaniment of the combined course of gastroesophageal reflux disease in young patients with autoimmune thyroiditis

Objective — to establish the presence of autonomic dysfunction and to assess the frequency and severity of its manifestations in patients with autoimmune thyroiditis (AIT) and gastroesophageal reflux disease (GERD) with...

Download PDF file
  • EP ID EP298596
  • DOI 10.30978/MG-2018-3-37
  • Views 110
  • Downloads 0

How To Cite

L. M. Bobro, T. V. Golovko (2018). Peculiarities of microbic landscape at NSAID-induced gastropathy in patients with diabetes mellitus. Сучасна гастроентерологія, 0(3), 37-41. https://europub.co.uk/articles/-A-298596