Peculiarities of rotavirus infection in children with different genotypes of the lactase gene
Journal Title: Медичні перспективи - Year 2014, Vol 19, Issue 4
Abstract
The aim was to study the peculiarities of rotavirus infection in children with various genotypes of the lactase gene LCT. Molecular genetic studies of LCT13910 gene polymorphism by polymerase chain reaction with electrophoretic detection were determined in the Institute of Genetic and Immunological basis of pathology and pharmacogenetics of "Ukrainian Medical Stomatological Academy", Poltava. According to the results of molecular genetic studies, all children were divided into three groups: the first group included 45 children with genotype C/C-13910, the second - 22 children with genotype C/T-13910, the third - 3 chil¬d¬ren with genotype T/T-13910. It is proved that in infants with rotavirus, the most common (63%) is genotype C/C-13910 of LCT gene. It is shown that a less severe form of the disease, which in most cases occurs without fever, a less duration of vomiting syndrome, a high incidence of respiratory syndrome, a less duration of illness are the peculiarities of rotavirus infection in children with genotype C/C-13910 LCT gene. Tendency to severe course with febrile fever, severe diarrhea, a high frequency of occurrence of expressed ketone blood syndrome, longer duration of disease may be considered to be features of rotavirus infection course in children with genotype C/T-13910 LCT gene.
Authors and Affiliations
A. Abaturov, Y. Stepanova, O. Gerasymenko
Keywords
Related Articles
- EP ID EP105486
- DOI -
- Views 117
- Downloads 0
A comparative evaluation of the antimicrobial activity of local antiseptics in revision hip arthroplasty
In our study there is presented information on the research of antagonistic activity of medications octenidine, decamethoxine, dioxydine, myramistin, povidone-iodine, chlorhexidine in standard dosage form and in dilution...
Updated approaches to the organisation of educational process
The article examines the main aspects of postgraduate education of junior specialists with medical or pharmaceutical education in Dnipropetrovsk region. Pedagogical innovations involves active learning, competency approa...
To 80-th birthday of our teacher – corresponding member of NAMS of Ukraine, doctor of medicine, professor O.V. Lyulko
Оксидантно-антиоксидантний баланс у крові і тканинах ясен щурів з експериментальним гастродуоденітом
С целью изучения начальных изменений в тканях пародонта при заболеваниях верхних отделов желудочно-кишечного тракта было про¬ведено исследование оксидантно-антиоксидантного баланса в тканях дёсен и сыворотке крови крыс...
Methods of diagnosing and restoring teeth abutments with different degrees of inclination in hard tissue defects and periodontal diseases
The need of Ukrainian population in treating damaged parts of the tooth crown is 36-53 % of all patients, individually made root - casted cores are commonly used in practical dentistry. Using teeth roots for prosthesis h...