Pelvic Exenteration for Recurrent Rectal Cancer: A Single Institution Experience
Journal Title: Turkish Journal of Colorectal Disease - Year 2021, Vol 31, Issue 1
Abstract
Aim: Rectal cancer is an important cause of cancer-related deaths worldwide (1-2). Although rectal cancers can be diagnosed earlier nowadays due to the development of screening programmes, 18% of patients have a locally advanced stage at the time of diagnosis (3). Despite the improvements in total mesorectal excision and oncological treatments, the locoregional recurrence rates vary between 6-10% in rectal cancer patients (4-5). Method: The data of patients who underwent pelvic exenteration for recurrent rectal cancer in our clinic between January 2015 and December 2019 were retrospectively analysed. Results: It was found that the patients with lymphovascular invasion (LVI) and perineural invasion (PNI) showed statistically poor survival rates (p=0.038/0.022). Two of the patients had a positive surgical margin and two others had a positive radial margin. There was no statistically significant difference between surgical margin positivity and prognosis (p>0.05). The mean number of metastatic lymph nodes was 4.0 (0-12), and the total number of lymph nodes was 12.35 (2-27). There was no statistically significant difference between patients with lymph node metastasis in terms of survival (p=0.079). Seven of the patients (41.1%) received systemic treatment before the surgery. It was statistically determined that the patients who received this treatment showed better survival rates (p=0.045). Conclusion: It was found that pelvic exenteration had a positive effect on survival and local recurrence in recurrent rectal cancer, and that neoadjuvant therapy increased survival rates.
Authors and Affiliations
Serdar Culcu, Cemil Yüksel, Mahmut Onur Kültüroğlu, Fatih Göksel, Eda Güner, Bülent Aksel,Lütfi Doğan
Keywords
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- EP ID EP693140
- DOI 10.4274/tjcd.galenos.2020.2020-8-1
- Views 111
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