PENENTUAN DOSIS MINIMUM EKSTRAK ETANOL HERBA KROKOT (Portulaca oleracea L.) TERHADAP PENURUNAN KADAR TRIGLISERIDA PADA TIKUS OBESITAS
Journal Title: As-Syifaa Jurnal Farmasi - Year 2018, Vol 10, Issue 2
Abstract
Common purslane (Portulace Oleracea L.) has a compound of omega-3, flavonoid and ascorbic acid with the activity in decreasing triglyceride levels. This study aimed to determine the minimum dose of ethanol extract of common purslane against the decrease of triglyceride levels of obese mice. It used 18 rats fed high-calorie diet (HCD) for 30 days. The obese rats were devided into 6 groups consisting of group I of negative controls (Na.CMC ), group II of positive control (gemfibrozil®), group III,IV,V,VI provided the ethanol extract of common purslane (EECP) with 25 mg/kgBW, 50 mg/kgBW, 75 mg/kgBW, 100 mg/kgBW. Afterwards, 14 days of therapy were given and still fed a high-calorie (HCD). The measurement of triglyceride levels is performed before induction (early). After induction , and after therapy. The data of the study were analized by percentage decrease of each test group. The result show that the EECP groups of 75 mg/kgBW was the minimum dose in lowering triglyceride levels with a decrease of 16,49 %.
Authors and Affiliations
Irma Santi, Rizqi Nur Azizah, Mu’ammar Mu’ammar
Keywords
Related Articles
- EP ID EP535289
- DOI -
- Views 66
- Downloads 0
AKTIVITAS ANTIFUNGI SARI DAUN PEPAYA (Carica papaya L.) TERHADAP Candida albicans
A research had been done on antifungal activity of papaya leaf ekstract (Carica papaya L.) and the aim was to determine the antifungal activity and inhibitory potency. The research was started by screening test using Ca...
STUDI PENGGUNAAN OBAT DIARE PADA ANAK PASIEN RAWAT INAP DI RSUD ANDI DJEMMA MASAMBA KABUPATEN LUWU UTARA PERIODE JANUARI-DESEMBER 2014
Diarrhea is generally caused by the bacteria contamined in food and drink. If the bacteria are not the right treatment, it can be fatal and cause death. This research aimed to present the drug use on the diarrhea patient...
HUBUNGAN LAMA PENGGUNAAN ALAT ORTODONTIK CEKAT TERHADAP AKUMULASI PLAK DAN pH SALIVA MAHASISWA FKG-UMI TAHUN 2017
Orthodontic treatment is a form of treatment in the field of dentistry which plays an important role in improving dental structure. Fixed orthodontic tools have an important role to obtain optimal and harmonic occlusion....
EFEK HEPATOPROTEKTOR EKSTRAK ETANOL RIMPANG DRINGO (Acorus calamus L.) TERHADAP PENINGKATAN KADAR SGPT TIKUS PUTIH (Rattus norvegicus)
Hepatoprotector is a liver protected-agent of hepatotoxic. This research was aimed to determine the hepatoprotector effect of ethanol extract of dringo rhizome (Acorus calamus L.) and most effective dose as a hepatoprote...
OPTIMASI PRODUKSI ANTIBIOTIKA ISOLAT TERPILIH FUNGI ENDOFIT IKD FF-UMI 02 DARI KULIT BUAH DELIMA (Punica granatum L.) DENGAN VARIASI SUMBER KARBON
Research of endophytic fungi of pomegranate fruit peel (Punica granatum L.), as Anti-free radicals and antibiotic has been done with DIKTI-PKM funding at 2014. It is considered necessary to further research about optimiz...