Pengujian Potensi Jus Tomat (Lycopersicum esculentum) Sebagai Terapi Herbal Pada Tikus Rattus norvegicus Hiperkolesterolemik
Journal Title: Biogenesis: Jurnal Ilmiah Biologi - Year 2016, Vol 4, Issue 2
Abstract
Hypercholesterolemia defines as the increasing of cholesterol serum that more than the normal limit. WHO (2011) on 2008 at Indonesian said that hypercholesterolemia prevalence of woman approach about 37,2% and for man about 32,8%. Tomato contain lycopene is one powerful antioxidant and can manage cholesterol metabolism with blocked the HMG-KoA enzyme reductase (enzyme for cholesterol synthesis in hepar). This study aims to determine the effect of tomato juice on the cholesterol levels in the blood of hypercholesterolemic rats and to find the effective dosis of tomato juice to decrease the cholesterol of hypercholesterolemic rats. The object of research covering 20 wistar rats (Rattus norvegicus) male 2-3 months old with 50-150g weight. The rats were divided into five groups and four replications: normal (K-), high-fat diet (K+), high-fat diet+tomato juice 200mg/100gBB (P1), high-fat diet+tomato juice 400mg/100gBB (P2), high-fat diet+tomato juice 800mg/100gBB (P3). Tomato juice was given orally for one month every day. At the end of the treatment of rats was dissected to take blood from the heart. Data were analyzed statistically with one-way ANAVA with α=0,05. The results showed that the tomato juice affects on the cholesterol levels of blood serum of hypercholesterolemic rats and the effective dose of tomato juice used in this study was 800mg/100gBB.
Authors and Affiliations
Dina Aribah, Alif Rofiqotun Nurul Alimah, Anindya Nirmala Permata, Betty Lukiati
Keywords
Related Articles
- EP ID EP300308
- DOI 10.24252/bio.v4i2.2512
- Views 170
- Downloads 0
Analisis Kandungan Vitamin Pada Melon (Cucumis melo L.) Kultivar Melodi Gama 1 dan Melon Komersial
As many as 50 million people worldwide are currently experiencing a deficiency of vitamin A and about 250000-500000 malnourished children in developing countries become blind each year from vitamin A deficiency, with the...
Karakteristik Mikrobiologis Kombucha Dari Berbagai Jenis Olahan Teh
This research aimed to analyze microbiological characteristics of kombucha from various types of tea processing which tasty to drink and gave benefits to examine some types of diseases. This research used an experimental...
Deteksi Odontoglossum ringspot virus Terhadap Anggrek Alam di Hutan Wonosadi, Gunung Kidul
Wonosadi forest is managed forests by indigenous forest communities and is located in the hamlet of Duren and Sidorejo, Beji village, subdistrict Ngawen, Gunung Kidul regency, Yogyakarta. One of the biological richness c...
Profil Hematologi Tikus (Rattus norvegicus Berkenhout, 1769) Galur Wistar Jantan dan Betina Umur 4, 6, dan 8 Minggu
Animal model is very important in biomedical research. Prior to apply in human or other primates, experiments using lower animals model such as rodents must be conducted (preclicical studies). Wistar rats (Rattus norvegi...
Status Padang Lamun Pantai-Pantai Wisata di Pacitan
The purpose of this research was to study the condition of seagrass communities at Pacitan coast. The study was conducted at Klayar, Srau, Teleng Ria, Pancer, Tawang, and Pidakan at Pacitan coast. The presence of seagras...