Pentosidine: Can Be Related To The Etiology Of Chronic Kidney Disease?
Journal Title: International Journal of Diabetology & Vascular Disease Research (IJDVR) - Year 2014, Vol 2, Issue 2
Abstract
Objectives: Advanced glycation end products (AGEs) and their receptors are prominent contributors to diabetic kidney disease. Clinical importance of AGEs toxicity in kidney disease etiologies had been rarely reported. We measured serum AGEs, sRAGE and Pentosidine levels in diabetic patients with and without nephropathy and examined whether these biomarkers are related to the etiologies of chronic kidney disease (CKD). Design and methods: We included 30 healthy control subjects and 116 diabetic patients who were further divided into 2 subgroups:one with 30 patients without CKD, the other with 86 CKD patients. AGEs, sRAGE and pentosidine were measured in serum by ELISA. Results: Serum levels of AGEs, sRAGE and pentosidine were significantly increased in diabetic patients without CKD compared to controls (579.78 ± 113.28 vs. 508.83 ± 119.68 pg/mL; 169.17 ± 30.41 vs. 148.72 ± 32.73 pg/mL; 247.84 ± 21.42 vs. 214.03 ± 55.05 pg/mL, P<0.001, P<0.01, P<0.05 respectively). In diabetic patients with CKD, serum AGEs, sRAGE and pentosidine levels were significantly higher than diabetic patients without CKD (P<0.001, P<0.01, P<0.001 respectively). Serum Pentosidine levels were increased in CKD patients with tubulointerstitial nephrophathy than other etiologies (P<0.001). Conclusions: Serum AGEs, sRAGE, and pentosidine levels are related with diabetic patients with and without CKD and pentosidine levels were increased in tubulointerstitial nephrophathy.
Authors and Affiliations
Mohsen Kerkeni
Keywords
Related Articles
- EP ID EP198704
- DOI 10.19070/2328-353X-140009
- Views 82
- Downloads 0
Prevalence of Major Risk Factors for Cardiovascular Disease in Patients With Diabetes. Data from The Ukrainian Endovascular Register
The analysis of the incidence of a number of risk factors for coronary heart disease in 2,700 people with angio-graphically documented coronary atherosclerosis in the electronic register of the Department of Intervention...
Blueberry Tea Enhances Insulin Sensitivity by Augmenting Insulin-Mediated Metabolic and Microvascular Responses in Skeletal Muscle of High Fat Fed Rats
Background: The aim of the current study was to determine whether a unique blueberry tea (BT) ameliorates insulin resistance by improving metabolic and vascular actions of insulin in skeletal muscle. Methods: Male Spragu...
Hyperglycemic Challenge And Distribution Of Adipose Tissue In Obese Baboons
Background: Blood glucose levels regulate the rate of insulin secretion, which is the body’s mechanism for preventing excessive elevation in blood glucose. Impaired glucose metabolism and insulin resistance have been lin...
Total Adiponectin and Risk of Symptomatic Lower Extremity Peripheral Vascular Disease in Type 2 Diabetes Mellitus
Objective: Adiponectin is an adipocyte-derived protein that has gained considerable research interest because of its pleiotropic effects on insulin sensitivity, atherosclerosis and inflammation. Lower concentrations of a...
Harmonizing Eating and Exercise Circadian Rhythms for Optimal Glucose-Insulin and Vascular Physiology.
This article establishes a global but individual public program based on rhythmic circadian eating and exercise extent and rate to harmonize intermediary metabolism. This will help optimize glucose assimilation and insul...