Perinatal complications in intrahepatic cholestasis of pregnancy
Journal Title: Journal of Oral Medicine, Oral Surgery, Oral Pathology and Oral Radiology - Year 2016, Vol 3, Issue 1
Abstract
Background and Objective: Intrahepatic cholestasis of pregnancy (ICP) is seen usually in 3 rd trimester of pregnancy. Overall incidence is 1.2-1.5% of Indian pregnant women. The biochemical abnormalities often include raised liver enzymes, conjugated bilirubin and bile acids. ICP can complicate perinatal outcomes to a significant extent. The present study was conducted to find out the types and incidence of perinatal outcomes in pregnancy complicated with ICP diagnosed by abnormal LFTS (liver function tests), to help the clinician in initiating timely treatment. Materials and methods: In the present study, 51 pregnant women diagnosed with ICP and 49 number of age and gravida matched normal pregnant women were included as cases and controls respectively. LFT and Total bile acids were estimated by standard biochemical methods. Both cases and controls were followed to evaluate perinatal outcomes after 7 days of postpartum. Results: Total bilirubin (0.6 ± 0.08 Vs 0.4 ± 0.03)milligrams/decilitre*; Aspartate transaminases (48 ± 18.6 Vs 27 ± 9.5) International Units/ Litre**; Alanine transaminase (42 ± 14.2 Vs 28 ± 6.1) International Units/ Litre**; Alkaline phosphatase (251 ± 63 Vs 159 ± 58) International Units/ Litre**;Gamma glutamyl transferase (41 ± 5.2 Vs 35 ± 3.6) International Units/ Litre**; Total bile acids (12.7 ± 10.2 Vs 33.4 ± 15.6)µ mol/ Litre ; Albumin (3.3 ± 0.5 Vs 3.2 ± 0.4)grams/decilitre; Total Proteins(6.3 ± 1.2 Vs 6.1 ± 1.5)grams/decilitre were obtained in cases Vs controls. Significantly higher incidence of total complications in cases compared to controls(54.90% Vs 12.24%)*** were found which include respiratory distress(23.52 Vs 4.08)%***, meconium aspiration (9.80 Vs 2.04)%**, pre-term delivery (9.80 Vs 4.08)%*, hyperbilirubinemia (1.96 Vs 0.0)%, fetal bradycardia (7.84 Vs 2.04)%** and fetal loss(1.96 Vs 0.0)%. (*p value<0.05, **p value<0.01, ***p value ˂0.001) Conclusion: The present study found an increase in incidence of total morbidity and mortality during perinatal period in babies born to women suffering from ICP. These findings suggests estimation of total bile acids and liver enzymes for early diagnosis of pregnant women at risk, active monitoring, treatment and induction of labor around 36-38 weeks after establishment of lung maturity in pregnancy associated with ICP to prevent perinatal complications.
Authors and Affiliations
Anuva Mishra, Akshaya Kumar Rath, Srikrushna Mahapatra, Pooja Priyadarsini
Keywords
Related Articles
- EP ID EP241937
- DOI -
- Views 123
- Downloads 0
Plasma cell gingivitis with aggressive periodontitis: A rare presentation of an uncommon condition
Background: Plasma cell gingivitis is a rare benign condition typified by non-neoplastic infiltrate of plasma cell into the gingival connective tissue. In most of the cases the underlying etiology is allergic reaction to...
Chronic osteomyelitis of maxilla: a rare case report
Osteomyelitis of the jaws is more common in developing countries and their treatment may be prolonged and difficult. Osteomyelitis is an acute or chronic inflammation involving both the cortical and trabecular aspects of...
Hypohidrotic ectodermal dysplasia- A case report
Ectodermal dysplasia is a hereditary disorder characterized by developmental dystrophies involving the ectodermal derivatives characterized by triad of signs comprising sparse hair missing or abnormal teeth and inability...
Histopathological correlation with computed tomography in respect to evaluation of paranasal sinus diseases
Introduction: Contrast enhanced CT scans are obtained only in patients who are acutely ill and suspected of having a complication of acute sinusitis. The present study was aimed to evaluate the spectrum of PNS diseases o...
Bilateral Inferiorly Based Nasolabial Flaps for the Management of “Oral Submucous Fibrosisâ€: A Case Report
Oral Submucous fibrosis [OSMF] is the premaligmant condition in which patient suffers from limited mouth opening and fibrous bands over buccal mucosa. Various medical and surgical modalities are being suggested in the li...