Periodontal Conditions during Arthritis Therapy with TNF-α Blockers
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 10
Abstract
ABSTRACT Introduction: Chronic Periodontitis (CP) and Rheumatoid Arthritis (RA) are both inflammatory diseases, characterised by severe inflammation of the associated tissues. Patients with RA have been reported to have poorer periodontal conditions such as more gingival bleeding, higher probing depth (PD) and Clinical Attachment Level (CAL) or missing teeth. However TNF-α blockers used in the treatment of RA seemed to positively influence the immune response of the periodontium. Aim: The aim of the present study was to verify if RA-patients under continuous medication with TNF-α blockers had better or worse periodontal health than non-RA-patients with periodontitis. Materials and Methods: The present case-controlled study included 13 patients with RA and 13 age and sex-matched non-RA periodontitis patients. In the RA-patients, RA-medication and duration of use were registered. In all patients Gingival Bleeding (GBI), Plaque Control Record (PCR), Bleeding on Probing (BOP), Probing Depth (PD), Clinical Attachment Level (CAL) and the number of teeth were recorded. For all patients the severity and extent of periodontitis was recorded respecting the classification system for periodontal diseases as well as serum level of C-Reactive Protein (CRP). Wilcoxon and Chi-square tests were performed for statistical analysis. Results: RA-patients had significantly less BOP (15.38% vs. 27.23%, p=0.045). RA-patients had a tendency to lower PD-values (2.54 mm vs. 3.15 mm, p=0.068) and fewer sites with PD≥5 mm (6.00 vs. 17.46, p=0.099). Comparing severity and extent of periodontitis RA-patients had significantly better periodontal conditions (p=0.033). No significant influence of the duration of RA-medication was found. Conclusion: RA-patients treated with TNF-α blockers for more than 12 months have better periodontal health than non-RA-patients with periodontitis. These findings can be explained through the benefits of the TNF-α medication for host immune modulation.
Authors and Affiliations
Rudolf Schiefelbein, Holger Friedrich Rudolf Jentsch
Keywords
Related Articles
- EP ID EP529819
- DOI 10.7860/JCDR/2018/36791.12158
- Views 82
- Downloads 0
Intraoperative Hyperkalemia Leading to Ventricular Tachycardia during Laparoscopic Renal Transplant
ABSTRACT Chronic kidney disease, consequent upon a variety of causes is a leading cause of morbidity and mortality. Renal transplantation is the preferred therapeutic approach for these patients. Hyperkalemia is a common...
Bite of a Mite: A Case of Human Otoacariasis caused by Cosmoglyphus Species (Acari: Acaridae)
Otoacariasis or parasitic otitis, is the infestation of the ear with ticks/mites and is a common condition in the livestock and domestic animals. Although, less common, cases of human otoacariasis caused by mites can be...
Ureteric Obstruction due to Aberrant Vessel Masquerading as Retrocaval Ureter
Abstract Aberrant vessels, although rare, may extrinsically compress ureter which on imaging may masquerade as retrocaval ureter. The exact cause of obstruction in such atypical cases can be confirmed intraoperatively....
The Leverage Method: A Novel Technique for Difficult Temporomandibular Joint Reduction
Letter to Editor
Image Findings of Solid Pseudopapillary Neoplasms of the Pancreas on Multiphasic Multidetector CT Scan– A Single Institute Experience from Southern India
Introduction: Solid Pseudopapillary Neoplasms (SPN) are uncommon pancreatic tumours and are slow growing with uncertain malignant potential, showing female preponderance. Postoperative prognosis is good and metastasis is...