Periodontal Disease and Neurodegeneration: The Possible Pathway and Contribution from Periodontal Infections
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 1
Abstract
ABSTRACT Neurodegeneration is a process in which the neurons lose its structure, function and ultimately the death of the neurons follows. Various neurodegenerative diseases like Alzheimer’s, Parkinson’s etc., are thus gaining enormous interest in health plans. Scientists are in search of finding the various markers to detect the onset of neurodegeneration. So far, Amyloid-beta (Aβ) and neurofibrillary tangle are the two markers found in most neurodegenerative diseases. Besides that, neural inflammation is also considered as one of the parameters for the onset of neurodegeneration. Inflammation may be caused either by insult of central nervous system or by peripheral infections. Numerous microbes get a chance to enter into the brain due to bacterial infection especially periodontal infection. The current review summarises the role of periodontal infection and the mechanism via which it contributes for neurodegeneration.
Authors and Affiliations
Rajeev Ranjan, Gyanaseni Dhar, Swetapadma Sahu, Nibedita Nayak, Monalisa Mishra
Keywords
Related Articles
- EP ID EP506122
- DOI 10.7860/JCDR/2018/29110.11045
- Views 57
- Downloads 0
Synovial Sarcoma of Palmar Aspect of Hand and Survival: A Rare Case Report
Synovial sarcomas of the hand are extremely rare entities than most soft tissue sarcomas. The location at finger is further rarer than carpus of the hand. Synovial sarcoma of the hand/finger initially confused with many...
The Prognostic Value of Different Molecular Subtypes of Breast Cancer in Relation to Enhancer-of-Zeste Homologue 2 Expression
ABSTRACT Introduction: The role of Enhancer-of-zeste homologue 2 (EZH2) in breast cancer invasion and progression may be attributed to EZH2-mediated epigenetic repression of tumour cells. Aim: The study aimed to assess t...
Effect of 12 Weeks of Yoga Therapy on Quality of Life and Indian Diabetes Risk Score in Normotensive Indian Young Adult Prediabetics and Diabetics: Randomized Control Trial
Introduction: India has become the epicentre for diabetes, a stress-related disorder affecting the working skills and day-today lifestyle management of younger population. Most of the studies have reported the effect of...
Surgical Implications of Portal Vein Variations and Liver Segmentations: A Recent Update
The Couinaud’s liver segmentation is based on the identification of portal vein bifurcation and origin of hepatic veins. It is widely used clinically, because it is better suited for surgery and is more accurate in local...
Infantile Alexander Disease: Case Report and Review of Literature
Alexander Disease (AD) is an autosomal dominant leukodystrophy and occurs predominantly in infants and children. It usually results in death within ten years after onset. Among the four subtypes, infantile form comprises...