Periodontal Disease and Neurodegeneration: The Possible Pathway and Contribution from Periodontal Infections
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 1
Abstract
ABSTRACT Neurodegeneration is a process in which the neurons lose its structure, function and ultimately the death of the neurons follows. Various neurodegenerative diseases like Alzheimer’s, Parkinson’s etc., are thus gaining enormous interest in health plans. Scientists are in search of finding the various markers to detect the onset of neurodegeneration. So far, Amyloid-beta (Aβ) and neurofibrillary tangle are the two markers found in most neurodegenerative diseases. Besides that, neural inflammation is also considered as one of the parameters for the onset of neurodegeneration. Inflammation may be caused either by insult of central nervous system or by peripheral infections. Numerous microbes get a chance to enter into the brain due to bacterial infection especially periodontal infection. The current review summarises the role of periodontal infection and the mechanism via which it contributes for neurodegeneration.
Authors and Affiliations
Rajeev Ranjan, Gyanaseni Dhar, Swetapadma Sahu, Nibedita Nayak, Monalisa Mishra
Keywords
Related Articles
- EP ID EP506122
- DOI 10.7860/JCDR/2018/29110.11045
- Views 40
- Downloads 0
Uterine Gangrene and Mechanical Intestinal Obstruction in a Teenager Following Unsafe Abortion
ABSTRACT Unsafe abortion often leads to complications since it is carried out by untrained persons in an unsafe environment. The most common complications are anaemia, bowel injury, bladder injury, uterine perforation, a...
Social and Psychological Safety of Adolescents with Intellectual Disabilities in Special and Inclusive Schools of Russia
ABSTRACT Introduction: The number of children with disorders of intellectual development in Russia in recent years have increased significantly around five percent. A significant proportion of adolescents with mental ret...
Combined Thrombophilia in a Young Male Presenting as Life Threatening Pulmonary Embolism
Combined hereditary thrombophilia is an uncommon entity associated with higher risk of early onset thrombosis. We report a case of 39-year-old male with combined deficiency of natural anticoagulants (protein C, S and ant...
Molecular Characterisation of Stenotrophomonas maltophilia in Nosocomial Infections: Challenges and Way Forward
ABSTRACT Introduction: Stenotrophomonas maltophilia (S. maltophilia), is an important rapidly emerging, opportunistic, non-fermenting Gram negative bacillus with high intrinsic resistance to drugs. It is one of the leadi...
Leiomyosarcoma of Renal Vein - A Rare Case Report
Leiomyosarcomas (LMS) arising from vascular channel are rare and more often arise from inferior vena cava and pulmonary arteries. Primary renal vein LMS are even rarer and occur predominantly in females with peak in fift...