Periodontal Involvement in Leukocyte Adhesion Deficiency: Review of the Literature and a Case Report
Journal Title: Journal of Dental School Shahid Beheshti University of Medical Sciences - Year 2016, Vol 34, Issue 2
Abstract
Objective: Leukocyte adhesion deficiency (LAD) is a rare, autosomal recessive inherited disorder; LAD-I which is the most common type, occurs due to mutations in the CD18 gene. This mutation down-regulates the expression of ß2 integrin leukocyte cell surface molecules, which are necessary for the adhesion of leukocytes to endothelial cells, transendothelial migration, and chemotaxis. The major symptoms are recurrent severe bacterial infections without pus formation, recurrent or progressive necrotizing soft tissue infections, marked leukocytosis and severe progressive periodontitis accompanied by alveolar bone loss, periodontal pockets, and partial or total early loss of primary and permanent teeth. Cases: Herein, we report a case of moderate LAD-I in a nine year-old boy with severe alveolar bone loss and aggressive periodontitis. For several years, approximately every month, the patient was followed up to evaluate the status of primary and permanent dentition. During these visits, scaling and root planing were performed and severely mobile teeth were extracted. The patient is now under regular follow up. Conclusion: This case confirms the need for interactions between the medical groups to identify and manage medically compromised children with rare diseases. It is important to include LAD in the differential diagnoses of children presenting with periodontal disease. Early correct diagnosis of LAD has various benefits for patients.
Authors and Affiliations
Nasim Seyfi, Mehrnoosh Sabzeghabaie, Sara Dehghankhalili
Keywords
Related Articles
- EP ID EP371122
- DOI -
- Views 80
- Downloads 0
Odontogenic Cysts: A 10-Year Retrospective Study in an Iranian Population
Objectives: The purpose of this study was to determine the frequency of all odontogenic cysts (OCs) along with age range, gender distribution, and the site of involvement over a 10-year period (March 2001 to March 2011)...
Analgesic Efficacy of Aloe Vera and Green Tea Mouthwash After Periodontal Pocket Reduction Surgery: A Randomized Split-Mouth Clinical Trial
Objectives: The aim of this study was to assess the efficacy of aloe vera and green tea mouthwash for reducing pain after periodontal pocket reduction surgery. Methods: This randomized, split-mouth, double-blind, cross-o...
Prosthetic Rehabilitation of Nasal Defect: A Case Report
Facial defects not only impact on the function and quality of life but also affect the psychological well-being and social behavior of patients. A nasal prosthesis can re-establish the esthetics and anatomical contour in...
A Model of Basic Dental Care Service for Iran
Objectives To study components of oral health care system in some developed countries and propose a model for Iran. Methods The present study was a qualitative, cross-sectional, and comparative research that took place i...
Comparing Post-Obturation of Apical Microleakage Following the Use of Different Intracanal Chelators
Objectives: Different chelators may be used during root canal treatment, offering various advantages including lubricant effect inside the canal and smear layer removal. However, chelator residues in narrow root canals c...