Peripheral blood eosinophilia in COPD: prevalence and clinical characteristics
Journal Title: Indian Journal of Basic and Applied Medical Research - Year 2018, Vol 7, Issue 2
Abstract
Background: Current evidence suggests that blood eosinophil levels are associated with COPD treatment response and natural history. This study assessed the prevalence of blood eosinophil count as a biomarker and investigated the clinical characteristics of COPD with peripheral blood eosinophilia. Materials and methods : Cross-sectional observational data from 120 subjects with age greater than 40 years with spirometry defined COPD and with absolute eosinophil count were analysed. Prevalence of peripheral blood eosinophilia and differences in clinical characteristics by absolute eosinophil count above and below 440 cells/cmm were evaluated. Results: Among COPD patients 38% had peripheral blood eosinophilia. Older age and male gender were associated with peripheral blood eosinophilia in COPD. Among COPD with eosinophilia other associated characteristics included higher BMI, lower FEV1 and FVC. Conclusion: The results suggests that the different level of blood eosinophils in the two groups may have influenced the pulmonary function tests independently and identify subgroups of subjects with specific disease characteristics.
Authors and Affiliations
ajitkumar C S
Keywords
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