Peroxidative metabolism of arachidonic acid in the course of Lyme arthritis
Journal Title: Annals of Agricultural and Environmental Medicine - Year 2015, Vol 22, Issue 3
Abstract
[b][/b]Objective. The objective of the study was measurement of serum arachidonic acid level as well as the product of its peroxidation – 8-isoPGF[sub]2[/sub][sub]α[/sub], and the activity of phospholipase A[sub]2[/sub] and PAF-acetylhydrolase that participate in releasing 8-isoPGF[sub]2α[/sub] from glycerol skeleton, and the potential designation of their role in the pathomechanism of Lyme disease (LD). Material and methods. Changes in the phospholipid arachidonic acid level and the level of 8-isoPGF[sub]2α[/sub] were determined in the plasma and urine of patients with LA (n=57) and of healthy controls (n=41). The activity of phospholipase A[sub]2[/sub] and PAF acetylhydrolase were assayed. All examined parameters were also measured in the plasma of some LA patients (n=13) after antibiotics treatment. Results. An almost 3-fold higher level of the total plasma 8-isoPGF[sub]2α[/sub] was observed in LA patients compared to the controls, while in the urine it increased over 5-fold. The plasma PLA[sub]2[/sub] activity was more than 3-fold higher in LA patients than in the healthy subjects, while PAF acetylhydrolase activity was observed to be modestly, but not significantly lower. The total 8-isoPGF[sub]2α[/sub] level in the plasma and urine of LA patients was significantly lower after antibiotics treatment. The plasma activity of PAF-AH in the LA patients was increased, while the cPLA[sub]2[/sub] activity decreased after antibiotics treatment. Conclusions. It may be suggested that in the course of LA, the level of binding 8-isoPGF[sub]2α[/sub] is significantly enhanced, and it may also be suggested that uncontrolled changes in the lipid status of some patients may make their Lyme arthritis unresponsive to antibiotics.
Authors and Affiliations
Wojciech Łuczaj, Anna Moniuszko, Magdalena Rusak, Joanna Zajkowska, Sławomir Pancewicz, Elżbieta Skrzydlewska
Keywords
Related Articles
- EP ID EP80988
- DOI -
- Views 122
- Downloads 0
Obstacles in diagnosing and confirmation of occupational diseases in private farming in Poland.
Features of the first alcohol test – subsequent attitude of 6 th year students at the State Medical University in Grodno, Belarus
[b]Objective.[/b] To clarify the mechanism of initiation of young people to alcohol, determine what factors influence this process, and identify the particular attitude to alcohol at a young age. [b]Materials and metho...
Level and determinants of physical activity among school adolescents in Poland
The recognition of adolescents’ physical activity has become one of the serious challenges of the modern times, as a concern about the future health of societies. The major goal of the presented study was to discover the...
Prevalence of contact allergy in children suffering from atopic dermatitis, seborrhoeic dermatitis and in healthy controls
Introduction: Atopic dermatitis is one of the most common skin disorders in children. There is only scarce literature data on the prevalence of contact allergy in children with atopic dermatitis.Objectives: To assess the...
Westernization of dietary patterns among young Japanese and Polish females – a comparison study
Introduction and objective. Nowadays, the process of the westernization of eating habits is perceived to be one of the main causes of epidemics of civilization diseases, such as metabolic syndrome. The aim of the study w...