Persistent cough as the sole manifestation of chronic eosinophilic leukemia (CEL) expressing FIP1L1-PDGFRA fusion gene
Journal Title: Postępy Nauk Medycznych - Year 2011, Vol 24, Issue 7
Abstract
We report on a male patient with persistent, non-productive cough. He has been receiving several oral and inhaled agents including steroids for the last 10 years. Two years before his current admission to Hematological Unit, an increased white blood cell (WBC) count with hypereosinophilia was documented with no further investigation. On admission his eosinophil count was 9.4 x 109/L with eosinophilic infiltration in marrow of 61%. The presence of FIP1L1-PDGFRA (F/P) fusion transcript was detected on molecular study and tyrosine kinase inhibitor-imatinib was initiated at a dose of 100mg daily. His eosinophil count dropped to 0.8 x 109/L with symptoms resolution merely 7 days after imatinib commencement. The repeated molecular study performed one month later did not detect the presence of F/P fusion. Currently, patient is free of any symptoms with normal eosinophil count while still on imatinib at 100 mg weekly.
Authors and Affiliations
Grzegorz Helbig, Anna Soja, Krzysztof Woźniczka, Andrzej Frankiewicz, Sławomira Kyrcz-Krzemień
Keywords
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