Persistent cough as the sole manifestation of chronic eosinophilic leukemia (CEL) expressing FIP1L1-PDGFRA fusion gene
Journal Title: Postępy Nauk Medycznych - Year 2011, Vol 24, Issue 7
Abstract
We report on a male patient with persistent, non-productive cough. He has been receiving several oral and inhaled agents including steroids for the last 10 years. Two years before his current admission to Hematological Unit, an increased white blood cell (WBC) count with hypereosinophilia was documented with no further investigation. On admission his eosinophil count was 9.4 x 109/L with eosinophilic infiltration in marrow of 61%. The presence of FIP1L1-PDGFRA (F/P) fusion transcript was detected on molecular study and tyrosine kinase inhibitor-imatinib was initiated at a dose of 100mg daily. His eosinophil count dropped to 0.8 x 109/L with symptoms resolution merely 7 days after imatinib commencement. The repeated molecular study performed one month later did not detect the presence of F/P fusion. Currently, patient is free of any symptoms with normal eosinophil count while still on imatinib at 100 mg weekly.
Authors and Affiliations
Grzegorz Helbig, Anna Soja, Krzysztof Woźniczka, Andrzej Frankiewicz, Sławomira Kyrcz-Krzemień
Keywords
Related Articles
- EP ID EP54219
- DOI -
- Views 127
- Downloads 0
Biopsy proven glomarulopathies at the Department of Nephrology, Medical Center for Postgraduate Medicine - analysis of 214 cases
We retrospectively evaluated the results of 214 renal biopsies performed in adult patients at the Department of Nephrology, Medical Centre of Postgraduate Education during 2005-2010. Patient age, indication for renal bio...
Późna diagnoza hiperoksalurii u chorej po przeszczepieniu nerki – opis przypadku
Pierwotna hiperoksaluria (PH) jest rzadką chorobą genetyczną prowadzącą do zwiększonego wydalania szczawianów wapnia oraz ich odkładania się w tkankach. Pierwsze objawy zazwyczaj pojawiają się poniżej 5. roku życia i obe...
Colorectal cancer
Colorectal cancer is a major oncological and health problem in Poland. Analysis of epidemiological trends indicate that the incidence of colorectal cancer will increase. Currently about 13 000 new cases are diagnosed ann...
Czy lipidy błonowe modyfikują aktywność receptorowych kinaz białkowych? Receptor epidermalnego czynnika wzrostu i jego oddziaływania z gangliozydami
Błona komórkowa jest niezwykle skomplikowaną strukturą, w obrębie której ostatnio wyróżniono wyspecjalizowane fragmenty, zwane tratwami lipidowymi, odpowiedzialne za regionalizację procesów życiowych komórki. Tratwy lipi...
Comment