Personalized Medicine Digoxin Theraphy in Individuals with MDR Gene Polymorphism
Journal Title: Indonesian Journal of Clinical Pharmacy - Year 2015, Vol 4, Issue 2
Abstract
Digoxin is one of digitalis drugs. Wider applicability to heart failure and arrhythmias (supraventricular) requires fairly strict scrutiny because of its narrow therapeutic index. Digoxin is a substrate of P-glycoprotein (P-gp) encoded by multi drugs resistance-1 (MDR1). MDR-1 gen located on chromosome 7q21.1. This gene contains 28 exons that encoded a protein of 1280 amino acids. This gene plays an important role in the absorption, distribution and elimination of many drugs. MDR1C3435T polymorphism occurs in exon 26. There are three types of MDR1C3435T gene namely MDR1C3435T CC, MDR1C3435T CT and MDR1C3435T TT. These polymorphisms will affect to the formation of P-gp and consequently to change the kinetic profile of digoxin. The change of kinetic profile causes changes in the digoxin blood levels. The method used in this review is data search based on pubmed, medline, and embase with keywords MDR and digoxin. There are several different studies of the influence of polymorphisms MDR1C3435T on blood digoxin levels. Increased levels of digoxin in the blood due to polymorphism of MDR1C3435T will be at risk of digitalis intoxication. Long-term digoxin treatment or large dose should consider the patient’s genetic profile. Distribution of polymorphism of MDR1C3435T in Javanese population is approximately TT (0,10), CT (0,52), and CC(0, 38).
Authors and Affiliations
Em Sutrisna
Keywords
Related Articles
- EP ID EP355554
- DOI 10.15416/ijcp.2015.4.2.113
- Views 111
- Downloads 0
Improving Outpatient’s Quality of Life through Patient Adherence of Antihypertensive Therapy Using “Mobile Phone (SMS) and Brief Counseling‑5A” in Polyclinic of Internal Medicine at PKU Muhammadiyah Bantul Hospital, Yogyakarta
The Health-Related Quality of Life (HRQoL) is one of the important psycho-social characteristics that can affect patient’s ability to manage therapy. Poor of knowledge of hypertension and the changing lifestyle can affec...
The Relationship of Lowering the Values of Bone Mineral Density in Methylprednisolone Medication Adherence on Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients
Methylprednisolone is a glucocorticoid which has a side effect of decreasing bone mineral density (DMT). The degree of compliance relates to the occurrence of effects. The objective of this study was to investigate the a...
The Impact of Performance Appraisal and Compensation to Performance of Pharmacy Technical Personnel Non-Civil Servants at Hasan Sadikin Hospital
Performance is the result of the quality and quantity of work achieved by an employee. This study aimed to determine the effect of performance appraisal and compensation to performance of Pharmacy Technical Personnel Non...
Effect of Pharmacist Home Care on Adherence of Hypertensive Patients
Based on data from Basic Health Research on 2013, the prevalence of hypertension was up to 25.8%. Hypertension can be controlled by taking medication regularly and healthy lifestyle. Factor that can improve the success o...
Assessment of Knowledge on Hypertension among Hypertensive Patients in Bandung City: A Preliminary Study
Hypertension is a common health problems that can increase the mortality and mobility rate in the community. As a silent killer, the prevalence of this disease is increasing worldwide. The prevalence of hypertension in I...