PERSPECTIVE IN THE TREATMENT OF ALZHEIMER’S DISEASE: PRE-CLINICAL STUDY
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 11
Abstract
Objective: This study end to investigate the efficacy of α-chymotrypcin in management of Alzheimer's disease (AD) in the experimental model.Methods: Sixty adult female albino rats were divided into four groups, (1) normal control group, (2) rats underwent surgery to remove ovaries (Ovex group), (3) Ovx rats received aluminum chloride to induced AD (AD group) and (4) AD rats treated with α-chymotrypcin (α-ch group).Results: In comparison with the normal control group, the Ovx group recorded significant increase in the brain level of transforming growth factor-β, while the brain levels of brain derived neurotrophic factor and vascular endothelial growth factor were significantly decreased. Similarly, AD group displayed the same effect versus the Ovex  group. Treatment of AD group with α-chymotrypcin resulted in significant improvement in the biochemical parameters as compared to untreated AD group. These results were confirmed by the histological examination of brain tissue. Conclusion: The current study suggests that α-chymotrypcin has a potent role in restraining AD due to its proteolytic and anti-inflammatory activity.
Authors and Affiliations
Samiha M Abd El Dayem, Fa Teheya Metwally, Hanaa H. Ahmed, Fatma M Foda, Aziza B Shalby, Asmaa M Zaazaa
Keywords
Related Articles
- EP ID EP579346
- DOI -
- Views 67
- Downloads 0
Research Paper DESIGN, OPTIMIZATION AND EVALUATION OF EMPAGLIFLOZIN ORODISPERSIBLE TABLETS USING DIFFERENT SUPERDISINTEGRANTS
Objective: The objective of this study was to formulate orodispersible tablets containing empagliflozin by direct compression method with sufficient hardness and rapid disintegration time and to study the effect of funct...
EXTEMPORANEOUS COMPOUNDING PRACTICE BY PHARMACISTS: A SYSTEMATIC REVIEW
Objective: To identify the frequency and scope of extemporaneous compounding practice reported in community and hospital pharmacies.Methods: A systematic literature review was undertaken to identify the prevalence of ext...
IDENTIFICATION OF SILDENAFIL CITRATE AS AN ADULTERANT IN HERBAL PRODUCTS USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY WITH PHOTODIODE ARRAY DETECTOR
Objective: Investigation of sildenafil citrate as an adulterant in the traditional liquid herbal products of the local market in Bangladesh.Methods: A reversed-phase high-performance liquid chromatographic (HPLC) method...
EVALUATION OF SAFETY PROFILES OF ANURADHA OIL-AN HERBAL WOUND HEALING FORMULATION IN LABORATORY ANIMALS
Objective: To investigate Acute, Sub-acute dermal toxicity, Mucus membrane irritation activity of Anuradha Oil’s (AO and AO11) – An herbal formulation having wound healing potential.Methods: The formulations were der...
FORMULATION DEVELOPMENT AND EVALUATION OF ORALLY DISINTEGRATING TABLET OF CHLORPHENERAMINE MALEATE BY SUBLIMATION TECHNIQUE
Objective: Chlorpheneramine maleate is a first-generation antihistamine drug used in the treatment of allergic conditions like rhinitis, urticaria, and cough cold, etc. In present work, the challenge has been made to dev...