Perspective of Direct Reprogramming of fibroblast to Cardiomyocyte
Journal Title: Perspectives In Medical Research - Year 2015, Vol 3, Issue 2
Abstract
Objective: A cure for cardiovascular disease remains a major unachieved medical need. Recent investigations have started to uncover the mechanisms of mammalian heart regeneration. Adult cardiomyocytes have slight regenerative capacity following injuries and also myocardium heals by fibroblast proliferation and scar formation. Mixtures of Cardiac-specific defined factors can generate cardiomyocytes from cardiac fibroblasts. By the use of Cardiac-specific transcription factors: Gata4, Mef2c, and Tbx5 (GMT), GMT plus Hand2 (GHMT), or Mef2c, Myocd, and Tbx5 in vitro Mouse fibroblasts can be directly converted into cardiomyocyte-like cells. Human fibroblasts can be reprogrammed into differentiated cardiomyocyte-like cells by overexpressing GMT plus Myocd and Mesp1 or Gata4, Hand2, Tbx5, Myocd, miR-1, and miR-133. Cardiac reprogramming technology may be a possible approach that could regenerate diseased hearts. This article reviews the current studies in cardiac reprogramming, and discusses the possibilities and disputes of direct cardiac reprogramming towards regenerative therapy.
Authors and Affiliations
Navid Noorali Shah
Role of ultrasound guided fine needle aspiration cytology in the diagnosis of abdominal-pelvic lumps
Background: Aspiration cytology is the study of cells, obtained by a fine needle puncture of the mass.The basic principles of fine needle aspiration can be applied to almost any site in the body.Masses arising in the abd...
Postnatal quality of life: A neglected research area in India
World Health Organization defines Quality of Life (QOL) as “individual's perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectation...
Seroepidemiological study of Herpes simplex virus 2 in Human Immunodeficiency Virus -1 seropositive individuals attending integrated counseling and testing centre in a tertiary care hospital in Warangal
Background: Herpes simplex virus type 2 (HSV2) transmitted via sexual route is now the most common cause of genital ulcers in developed and developing countries. Increasing evidence demonstrates a substantial link betwee...
Obstructive Sleep Apnea Hypopnea Syndrome – Indian scenario
Obstructive sleep apnea syndrome is far more common than generally believed. The Indian population where obesity rates are also increasing also has a very large population with undiagnosed OSAHS. The association of OSAHS...
Prevention of preeclampsia: The need of the hour
contributor for the maternal deaths in the developing world. The risk that a woman will die of preeclampsia or eclampsia in a developing country is 300 times more than that a woman in a developed country.1 Also the adver...