Perspective of Direct Reprogramming of fibroblast to Cardiomyocyte
Journal Title: Perspectives In Medical Research - Year 2015, Vol 3, Issue 2
Abstract
Objective: A cure for cardiovascular disease remains a major unachieved medical need. Recent investigations have started to uncover the mechanisms of mammalian heart regeneration. Adult cardiomyocytes have slight regenerative capacity following injuries and also myocardium heals by fibroblast proliferation and scar formation. Mixtures of Cardiac-specific defined factors can generate cardiomyocytes from cardiac fibroblasts. By the use of Cardiac-specific transcription factors: Gata4, Mef2c, and Tbx5 (GMT), GMT plus Hand2 (GHMT), or Mef2c, Myocd, and Tbx5 in vitro Mouse fibroblasts can be directly converted into cardiomyocyte-like cells. Human fibroblasts can be reprogrammed into differentiated cardiomyocyte-like cells by overexpressing GMT plus Myocd and Mesp1 or Gata4, Hand2, Tbx5, Myocd, miR-1, and miR-133. Cardiac reprogramming technology may be a possible approach that could regenerate diseased hearts. This article reviews the current studies in cardiac reprogramming, and discusses the possibilities and disputes of direct cardiac reprogramming towards regenerative therapy.
Authors and Affiliations
Navid Noorali Shah
Keywords
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