Perspectives on the Global Impact and Effectiveness of Covid-19 Vaccines against Emerging SARS-Cov-2 variant Omicron
Journal Title: Advances in Clinical Toxicology - Year 2022, Vol 7, Issue 1
Abstract
The new Omicron (B.1.1.529) variant of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported on November 2021 in South Africa and classified as a variant of concern by WHO. It spread globally in a very short span and became a predominant variant in several countries. The emerging Omicron variant is a highly transformed virus with more than 50 mutations, and the majority were found in Spike (S) protein that interacts with human cells. This Covid-19 outbreak resulted in more than 5 million deaths with an ongoing hike in morbidity and mortality, leaving economic recession worldwide. Currently, several Covid-19 vaccines have been approved that mainly were rely on S-protein. As the SARS-CoV-2 virus evolves to get fit and escape host immunity, the effectiveness of existing Covid-19 vaccines against the new variants needs to be addressed. Here, we have presented various perspectives on the global impact of new variant Omicron and ongoing vaccine developments to fight against dangerous future variants with high transmissibility and evade host neutralizing antibodies.
Authors and Affiliations
Golla U*, Dallavalasa S, Manda NK, Nalla S and Singh S*
Keywords
Related Articles
- EP ID EP751941
- DOI 10.23880/act-16000230
- Views 35
- Downloads 0
Phytochemical Investigations and Antioxidant Properties of Iris Kashmiriana Leaves Family-Iridaceae
Antioxidants are nature’s way of protecting the body and cells from damaging free radicals. Free radicals are unstable molecules that are generated by sun exposure, straks and a part of natural aging process, and preven...
Easiest and Accurate Confirmation of Early Pregnancy during Autopsy
One of the causes for suicide in young and unmarried females is relationship without wed-log which turns into pregnancy. Due to failure of relationship or to hide the condition and guilt, they commit suicide. Sometimes d...
Transforming Toxicity Assessment through Microphysiology, Bioprinting, and Computational Modeling
Background:Traditional toxicity testing emphasizes animal models with growing concerns regarding predictive capacity, throughput and ethics. Rapid innovation surrounding human cell platforms, bioengineered tissues, omics...
Genotoxicity, Acute and Sub-Chronic Toxicity Studies of Solid-State Cultivated Mycelial Powder of Antrodia cinnamomea
Antrodia cinnamomea is a precious medicinal mushroom endemic to Taiwan that has been used as folk medicine for health promotion and treating various diseases. In this study, the toxicological assessment of solid-state c...
COVID-19 Implication by Physical Interaction of Artificial fog on Respiratory Aerosols
Background: Artificial fog consists of small liquid aerosols suspended in air which reduce visibility and reflect light. Artificial fog is used in the film, television, and live entertainment industries to enhance lighti...