Pharmaceutical Analysis of Different Brands of Solifenacin Tablets Available in Pakistani Market
Journal Title: RADS Journal of Pharmacy and Pharmaceutical Sciences - Year 2018, Vol 6, Issue 2
Abstract
Objective: The current study was designed to evaluate and compare the quality and physiochemical characteristics of three different most commonly used brands of Solifenacin (10 mg) tablets available in Karachi, Pakistan. Methods: Both the official and non-official tests were applied for the assessment of physical tests, such as hardness, thickness, weight variation, friability, disintegration and chemical tests like dissolution profile and assay using already reported HPLC method. Model independent approach like similarity factor (f2) was also applied to compare the dissolution profile of generic drug products with reference (innovator). Results: The results of physical and chemical test showed that that all brands of Solifenacin were within the specified limits. The amount of Solifenacin in all three brands was within the USP specification of not less than 80% at 45 minutes. Similarly, the value of f2 indicated that all the brands were found to be similar with reference (innovator). Conclusion: This study will help physicians and pharmacists for the selection of most appropriate quality brand for the treatment of active urinary bladder and in-continence episodes of urination.
Authors and Affiliations
Muhammad Iqbal Nasiri
Keywords
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