PHARMACEUTICAL ASSESSMENT OF THERMOSENSITIVE HYDROPHILIC GELS WITH POLYVINYL PYRROLIDONE K-30 CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN
Journal Title: Progress on Chemistry and Application of Chitin and its Derivatives - Year 2013, Vol 0, Issue
Abstract
Gels containing lactic acid complexed with chitosan at a stoichiometric ration 1:1 and 2:1 and 5 - 25% content of polyoxyethylene glycol 200 are able to move from 25 to 30 cm. Measurements performed in a biopharmaceutical model revealed that the addition of 20% poloxamer 407 to gels containing lactic acid complexed with chitosan in a stoichiometric ration 1:1 decreases their movability from 20 to 25 cm and at 2:1 ratio, from 22 to 28 cm. Higher concentrations of the poloxamer 407: 23 and 25% result in the movability of 20 to 24 cm. The addition of 5% PVP K-30 besides 1,2-propylene glycol increases the movability gels containing lactic acid complexed with chitosan in a stoichiometric ration 1:1 from 24 cm to 28 cm and at 2:1 ratio from 26 cm to 30 cm. Higher concentrations of the poloxamer 407: 23 and 25% result in the movability of 24 to 27 cm.
Authors and Affiliations
Katarzyna Małolepsza-Jarmołowska
Keywords
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- EP ID EP73500
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