PHARMACEUTICAL EVALUATION OF FOUR BRANDS OF ATENOLOL TABLETS AVAILABLE IN OMAN
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2013, Vol 2, Issue 6
Abstract
Atenolol is a widely used drug for treating heart conditions available worldwide under various trade names by several generic pharmaceutical manufacturers. Atenolol is a selective β1 receptor antagonist, a drug belonging to the group of beta blockers, a class of drugs used primarily in cardiovascular diseases. The Atenolol is recognized and extensively prescribed as first choice of drugs in the treatment of majority of the hypertension population. The conventional formulation of these drugs is rapidly dissolved in upper gastric intestine and produces peak plasma concentration within 1 to 4 hours and then declines quickly. Aim: The aim of the present study was to evaluate the pharmaceutical equivalent of different brands of atenolol tablets. Materials and Methods: Four different brands atenolol of 100 mg tablets have been evaluated using some quality control test of weight variation, friability, hardness and disintegration with aim to assess whether these 4 brands are pharmaceutically equivalent or not. The results obtained have been compared with USP standards. Result: The results indicated that all the tablets in the three brands have met the requirements of the quality control test (weight variation, friability, hardness and disintegration) according to the USP which indicated that they are pharmaceutically equivalent.
Authors and Affiliations
Nirmala Halligudi*| Department of Pharmacy and Natural Science, Oman Medical College, Muscat, Oman, and Salim Musabah Al-Mubihsi| Department of Pharmacy and Natural Science, Oman Medical College, Muscat, Oman
Keywords
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