Pharmaceutical Quality Analysis of Ceftriaxone Sodium Brands Marketed in Southern Nigeria
Journal Title: Journal of Pharmaceutical Research International - Year 2016, Vol 9, Issue 5
Abstract
One of the paramount controversies between Physicians and Pharmacists is the issue of generic substitution. Prescribers are compelled to choose from such a large range of brands. The objective of this study was to compare the Pharmaceutical quality of innovator brand of injectable Ceftriaxone sodium with its generic brands that are marketed in Southern Nigeria. Seven brands of injectable Ceftriaxone sodium marketed in some pharmacies in Southern Nigeria were analysed. Standard physical and chemical tests for quality control of parenterals approved by the British Pharmacopoeia were performed on the branded sampled. The tested brands complied with the BP specifications for quality of Parenterals. Although one of the generic brands has content weight of Ceftriaxone greater than the upper limit specified (127.906%). The brands of Ceftriaxone sodium tested have been proven to be pharmaceutically and therapeutically equivalent. Though, there are variations among these brands due to the different manufacturing processes and formulation factors.
Authors and Affiliations
Ogbonna Okorie, E. Omotoso Abayomi, Ebinyansi Onyinyechi
Keywords
Related Articles
- EP ID EP342254
- DOI 10.9734/BJPR/2016/19577
- Views 100
- Downloads 0
Alpha-amylase Inhibitory Compounds from Musa cavendishii
Aims: To investigate the ethyl acetate fraction from the methanol extract of the leaves of Musa cavendishii and to evaluate the alpha-amylase inhibitory activity of its isolated phytochemicals and their va...
Monitoring of Pesticide Poisoning in Different Occupational Groups by the Estimation of Serum Cholinesterase (PChE), ALT, AST & Bilirubin
Objectives: An increasing number of reports suggest that chemical and physical agents in the environment, introduced and spread by human activity may affect human liver. The present study was conducted to find out pestic...
In vitro Antisalmonellal and Antioxidant Activities of the Crude Extracts and Fractions from the Stem Bark of Albizia gummifera (J. F. Gmel.) C. A. Sm.
Aims: Typhoid fever is an infectious disease, which continues to be a serious health problem and remains a major cause of morbidity and mortality in the developing country. Considering the ethnopharmacological relevance...
Hospital Pharmacists’ Participation in Multidisciplinary Ward Rounds: Physicians’ Perceptions and Attitudes
Aims: To survey the physicians’ perceptions and attitudes towards pharmacists’ participation in multidisciplinary ward rounds (MDWRs) and to ascertain their acceptance of such practice in the University of Maiduguri Teac...
Stability Indicating RP-HPLC Method for Simultaneous Estimation of Atazanavir and Cobicistat in Tablets
Aim: The aim of this study was to develop a stability indicating RP-HPLC method for simultaneous quantitative analysis of atazanavir and cobicistat in tablets. Place and Duration of Study: At Rainbow Pharma Training Lab,...