PHARMACEUTICAL STANDARDIZATION OF APAMARGA KSHARA YOGA
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2015, Vol 5, Issue 6
Abstract
Objective: Apamarga Kshara Yoga (APK), a classical Ayurvedic formulation containing Apamarga Kshara (alkaline substance of Achyranthes aspera Linn.), Manahshila (Arsenic Disulphide) and Gomutra (cow’s urine) is effective in cases of Shvitra (vitiligo). As the formulations has short shelf life, inconvenient to patients and involve longer duration of pharmaceutical preparation; it is planned to convert into more convenient form. Design: Raw materials were authenticated and APK was prepared. Further, organoleptic and physico-chemical properties were evaluated. Results: An average 909.8 gm (90.98 %) yield after Taila Paka and 1379.6 gm ointment was observed in the process. Conclusions: As observed in present study, addition of wax to attain ointment consistency is mandate. Residue as Apamarga Kshara and Manahshila incorporated in preparation of ointment yielded more without losing its consistency.
ENHANCEMENT OF ORAL UPTAKE OF AMIKACIN USING COPOLYMERS
Amikacinis a semisynthetic derivative of Kanamycin; it was approved for clinical use in the U.S. in 1976. Amikacin is broad-spectrum and potent aminoglycoside with limited clinical use owing high dose requirement.Many gr...
FORMULATION AND EVALUATION OF BILAYER TABLETS OF BACLOFEN USING SYNTHETIC POLYMERS
Aim of study was to develop bilayer drug delivery for treatment of spasticity by delivering loading and maintenance dose for fast achievement of peak plasma concentration and maintaining the same respectively. The prepar...
FUNDAMENTAL ASPECTS IN THE DEVELOPMENT OF MICROEMULSION SYSTEMS CONTAINING AMPHOTERICIN B FOR OPHTHALMIC USE
This is an overview of the development of microemulsion systems containing amphotericin B for ophthalmic use. The amphotericin B (AmB) is used to treat a fungal infection of eye and bioavailability of the AmB is the chal...
FORMULATION AND EVALUATION OF CONTROLLED POROSITY OSMOTIC PUMP TABLETS FOR ZIDOVUDINE AND LAMIVUDINE COMBINATION USING FRUCTOSE AS OSMOGEN
The present study deals with the development and evaluation of controlled porosity osmotic pump (CPOP) tablets of zidovudine-lamivudine. Wet granulation method was used for the development of core tablets. Core tablets w...
DESIGN AND EVALUATION OF COLON TARGETED DELIVERY OF TEGASEROD MALEATE FOR IRRITABLE BOWEL SYNDROME
The colon is being extensively investigated as a drug delivery site. Colonic drug delivery is a relatively recent approach for the treatment of diseases like ulcerative colitis, Crohn’s disease, and irritable bowel syn...