Pharmacodynamic and Pharmacokinetic Comparison between Selective and Non-selective COX-2 Inhibitors in Mice
Journal Title: Journal of Applied Veterinary Sciences - Year 2024, Vol 9, Issue 2
Abstract
Nowadays, there is a need for good and efficacious NSAIDs with minimal side effects to be applied in veterinary medicine. The aim was to compare the pharmacodynamics (analgesia and inhibition of COX-2) and pharmacokinetics between selective (nimesulide) and non-selective (aspirin) COX-2 inhibitors in mice. Assessing the median effective doses by using the up-and-down method, COX-2 activity and plasma concentrations for both nimesulide and aspirin with their pharmacokinetic profiles in mice. The median effective doses (ED50s) of nimesulide and aspirin were found to be 7.9 and 212.23 mg/kg, respectively, using the hot-plate. Both nimesulide (15.8 mg/kg, i.m.) and aspirin (424.5 mg/kg, i.m.) inhibited COX-2 activity through a decrease in COX-2 concentrations in the plasma, liver, and kidney of mice, with superior inhibition when administering nimesulide in comparison to the control (negative and positive) and aspirin-treated groups. Plasma concentrations of nimesulide (15.8 mg/kg, i.m.) measured for different comparable periods of 0.5, 1, 2, 4, and 24 hours were higher than those of aspirin, which were 14.62, 9.22, 9.88, 7.38 and 2.27 µg/ml, respectively, while aspirin (424.5 mg/kg, i.m.) was 4.35, 3.17, 2.54, 2.25 and 1.21 µg/ml, at the same measured times. Nimesulide pharmacokinetic variables were estimated to be AUC0-â 169.18, AUMC0-â 2358,72, Kel  0.06, Cmax 14.62, Tmax 0.5, t1/2β 11.07, MRT 13.94, Vss 1.49, and Cl 0.09, while aspirin pharmacokinetic parameters differed to be 82.31, 2428.32, 0.03, 4.35, 0.5, 21.25, 158.12, and 5.16, respectively. The study concluded that nimesulide has superior pharmacological properties (analgesic, antipyretic, and anti-inflammatory) than aspirin due to its ability to inhibit COX-2 more selectively and its unique pharmacokinetics in mice, which may be useful in veterinary medicine.
Authors and Affiliations
Taimaa Yahya,Yaareb Mousa,
Keywords
Related Articles
- EP ID EP733331
- DOI -
- Views 38
- Downloads 0
Effect Of Garlic As Feed Additive On Performance, Carcass Characteristics, And Meat Quality Of Muscovy Ducks Reared In Different Stocking Densities
This study was carried out to evaluate the effect of supplementing diet with different garlic powder concentrations (300 and 600gm/Ton) on performance, carcass characteristics and meat quality (fat %) of Muscovy ducks ex...
Evaluation Of Bivalent Inactivated Infectious Bronchitis Viral Vaccine Prepared From Local Isolates
Infectious Bronchitis (IB) is currently one of the most important diseases in poultry flocks all over the world causes huge economic losses in poultry industry. Many IBV outbreaks associated with respiratory distress, ne...
Impact Of Continuous Treatment With Propylthiouracil On Renal And Hepatic Functions In Rabbits
This study was designed to investigate the effect of continuous treatment with the anti-thyroid drug, propylthiouracil (PTU), on renal and hepatic functions in rabbits as an experimental animal model. Animals were random...
Histopathological and the Dose Depended Effects of Aspartame toxicity on Liver and Kidney of Rats
Aspartame is a commonly employed artificial sweetener used by hyperglycemic patients and in food management. Its danger depends on the outcome of previous studies that revealed controversy. The purpose of this study was...
Seroprevalence of toxoplasma gondii and brucella abortus in dairy animals from the Sudan: special emphasis to their serological co-existence
Toxoplasmosis and brucellosis are the most common zoonotic food borne diseases worldwide. The abortion caused by these agents is one of the major causes of socio-economic losses in human and livestock. We thus conducted...