Pharmacogenomics: The promise of personalized medicine
Journal Title: The AAPS Journal - Year 2000, Vol 2, Issue 1
Abstract
Authors and Affiliations
Laviero Mancinelli, Maureen Cronin, Wolfgang Sadée
Keywords
Related Articles
- EP ID EP682078
- DOI 10.1208/ps020104
- Views 71
- Downloads 0
Mechanisms of methamphetamine-induced dopaminergic neurotoxicity
Methamphetamine (METH) is a powerful stimulant of abuse with potent addictive and neurotoxic properties. More than 2.5 decades ago, METH-induced damage to dopaminergic neurons was described. Since then, numerous advancem...
Endocannabinoid mechanisms of pain modulation
Cannabinoids are antinociceptive in animal models of acute, tissue injury-, and nerve injury-induced nociception. This review examines the biology of endogenous cannabinoids (endocannabinoids) and behavioral, neurophysio...
Formulation design of double-layer in the outer shell of dry-coated tablet to modulate lag time and time-controlled dissolution function: Studies on micronized ethylcellulose for dosage form design (VII)
The dry-coated tablet with optimal lag time was designed to simulate the dosing time of drug administration according to the physiological needs. Different compositions of ethylcellulose (EC) powder with a coarse particl...
Properties of thalidomide and its analogues: Implications for anticancer therapy
Thalidomide and its immunomodulatory (IMiDs) analogs (lenalidomide, Revlimid, CC-5013; CC-4047, ACTIMID) are a novel class of compounds with numerous effects on the body's immune system, some of which are thought to medi...
Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations, Part 6: Effects of Varying Pancreatin and Calcium Levels
The online version of this article (doi:10.1208/s12248-014-9672-x) contains supplementary material, which is available to authorized users.