Pharmacokinetic interaction of tulathromycin with Flunixin meglumine after intravenous injection in goats
Journal Title: Journal of Veterinary Medical Research - Year 2016, Vol 23, Issue 2
Abstract
The pharmacokinetic aspects of tulathromycin (2.5 mg/kg b.w.) were studied following intravenous administration alone and in combination with flunixin meglumine (2.2 mg/kg b.w) in apparently healthy goats. Tulathromycin concentrations in serum were determined by microbiological assay technique using Bacillus subtiles (ATCC 66343) as test organism. The half-lives of distribution and elimination (t0.5(a)and to.5(p)) were 0.071, 0.046 and 6.43, and 5.05 h. following intravenous injection of tulathromycin alone and in combination with flunixin, respectively. Volume of distribution at steady state (Vdss) was 0.249 and 0.96l/kg., mean residence time (MRT) was 6.27 and 5.99 h and total body clearance (ClB) was 0.046 and 0.17 l/kg/hr., respectively. It was concluded that flunixin significantly altered the pharmacokinetics of tulathromycin by increase its distribution and accelerate its elimination from body. Therefore care should be taken during use of tulathromycin in goats concurrently with flunixin.
Authors and Affiliations
M. Adam, M. A. Tohamy, S. E. El-Sadek, Abeer M. Radi
Keywords
Related Articles
- EP ID EP658396
- DOI -
- Views 241
- Downloads 0
Decontamination of broiler carcasses` skin using medicinal herbal extracts
This study was carried out to detect the efficiency of different concentrations of medicinal herbal extract as decontaminant agent on broiler carcasses. Therefore, a total of twelve broiler carcasses treated with sumac e...
Bacteriological studies on bacterial pathogens isolated from broiler chickens with swollen head syndrome
This work was planned to investigate the bacteria isolated from broiler chickens head suffered from naked eye pathological lesions. Out of 200 examined head lesions, the result revealed that the major pathogens associate...
Current situation assessment of biosecurity measures of some poultry sectors and hatcheries in Egypt
Preventing the transmission of disease into and between poultry farms, hatcheries, and from wildlife, or their droppings, is essential to maintain healthy productive poultry flocks. This study was designed to assess the...
Rumen impaction in cattle due to plastic materials
The present study was carried out on 22 cows suffering from ruminal impaction with plastic materials as foreign bodies and ten apparently healthy cows as a control group. Clinical examination included clinical signs, tem...
Efficacy of fosfomycin in controlling streptococcosis in Nile tilapia (Oreochromis niloticus)
A study was conducted to investigate the efficacy of fosfomycin in controlling streptococcosis in Nile tilapia (Oreochromis niloticus). The minimum inhibitory concentrations (MICs) of fosfomycin against multiple S. iniae...