PHARMACOKINETICS OF CIPROFLOXACIN IN PIGS AFTER SINGLEINTRAVENOUS AND INTRAMUSCULAR ADMINISTRATION
Journal Title: TRADITION AND MODERNITY IN VETERINARY MEDICINE - Year 2017, Vol 2, Issue 2
Abstract
The pharmacokinetics of ciprofloxacin in pigs after single intravenous or intramuscular application was followed out. Blood concentrations were assayed using HPLC with UV-detection. By means of the TopFit, v. 2.0. software, the pharmacokinetic parameters were calculated by two pharmacokinetic models – compartmental and non-compartmental. After i.v. application, the respective values of calculated pharmacokinetic parameters were as followed: t1/2α = 0.54 h; t1/2β = 5.92 h and t1/2β = 5.76 h; MRT = 8.74 h and MRT = 8.41h; AUC0→∞= 23.14 µg.h/ml and AUC 0→∞ = 22.24 µg.h/ml; Vss= 4.87 l/kg and Vd(area) = 5.14 l/kg. After i.m. application of ciprofloxacin, the respective values of calculated pharmacokinetic parameters were as followed: t1/2α = 0.46 h; t1/2β = 4.83 h and t1/2β = 4.61 h; MRT = 9.89 h and MRT = 9.68 h; t1/2abs. = 0.56 h; MAT = 1.15 h and MAT = 1.12 h; Cmax = 0.714 µg/ml and Cmax = 0.625 µg/ml; Tmax= 0.76 h and Tmax= 0.88 h; AUC0 = 17.630 µg.h/ml and AUC0 = 16.835 µg.h/ml; F = 76.23% and F = 75.69%.
Authors and Affiliations
Dimitrichka Dimitrova, Sofiya Ivanova, Metodi Petrichev
Keywords
Related Articles
- EP ID EP234860
- DOI -
- Views 137
- Downloads 0
RED AND WHITE BLOOD PROFILE IN RABBITS AFTER EXPERIMENTALLY INDUCED INFECTION WITH SPORULATED OOCYSTS OF EIMERIA STIEDAE
The aim of this study was to identify changes in parameters of blood count in rabbits with experimentally induced liver coccidiosis. In the experiment were used 12 New Zealand White rabbits, divided into experimental and...
QUALITY AND SAFETY OF FEED USED IN FEEDING CATTLE
This article addresses issues related to the quality and safety of feed and additives used in the feeding ofcattle. The indicators characterizing the quality of feed – dry matter, energy, crude protein, digestible protei...
ATYPICAL MYCOSIS IN WILD BOARS
From skin of wild boars with signs of dermatitis were isolated fungi of species Penicillium verrucosum (Dierckx, 1901), and Aspergillus fumigatus (Fresen, 1863). Pathologically were stablished hepatitis and nephritis. A....
CLINICAL AND HEMATOLOGICAL STUDIES IN SHEEP WITH SUBCLINICAL AND CLINICAL KETOSIS
The investigation was performed on 136 ewes, 106 (Lacaune) and 30 (Mouton Charollais). The ewes were divided in three groups: pregnant; recently lambed and lactating. Sheep of the three groups, we performed a chemical bl...
BIOACCUMULATION OF METALS IN TISSUES AND HELMINTHS OF HARES IN KARDZHALI REGION
This study was aimed to evaluate content of heavy metals in Lepus europeas Pallas 1778 and its helminth Trichuris sylvilagi (Nematoda) in Kardzhali region, Bulgaria. The contents of Cd, Pb, Zn, Mo, Mn, and Co were determ...