PHARMACOKINETICS OF LINCOMYCIN FOLLOWING SINGLE INTRAMUSCULAR ADMINISTRATION IN GOATS
Journal Title: International Journal of Agricultural Science and Research (IJASR) - Year 2017, Vol 7, Issue 2
Abstract
Pharmacokinetics of Lincomycin following intramuscular administration at dose rate 10 mg/kg body weight was investigated in healthy goats. Blood samples were collected from 1 min to 24 h of drug administration. The disposition of Lincomycin followed two compartment open model and drug was detected in plasma up to 8 h. The peak plasma concentration (Cmax) was observed 5.63 ± 2.50 µg.ml-1at 0.20 ± 0.16 h (Tmax) after intramuscular injection of Lincomycin. Absorption half life (t1/2ka) was very short (0.05 ± 0.01 h) indicated faster absorption of drug and low value of the distribution coefficient (1.50±0.36 h-1) showed slow distribution from blood to tissues. The high AUC (33.8±7.68μg.h/mL) indicated good antibacterial activity of Lincomycin. The elimination half life, volume of distribution and total body clearance were 6.19±0.25 h, 2.95±0.50L/kg and 0.52±0.24L/h/kg, respectively. The long elimination half life indicated drug retain for longer period in body. Based on results, Lincomycin is suggested to be repeated at 12 h interval for organisms are sensitive to Lincomycin having MIC up to 0.6 µg/mL.
Authors and Affiliations
MEEMANSHA SHARMA, BHASKAR VEMU, VINOD KUMAR DUMKA
Keywords
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