Pharmacological and analytical aspects of artemisinin for malaria: Advances and challenges
Journal Title: Asian Pacific Journal of Tropical Medicine - Year 2019, Vol 12, Issue 8
Abstract
Malaria remains a major tropical health burden owing to the development of resistance and decreased sensitivity to the frequently used conventional antimalarial drugs. The drug like artemisinin possesses potent antimalarial activities, but has some limitations. Therefore, new strategies are to be implemented for optimal utilization of artemisinin to improve its therapeutic effectiveness and to overcome its limitations. The present review focuses on present scenario of malaria and pharmacological as well as analytical aspects of artemisinin. Data from 2000 to 2018 were collected from NCBI for understanding the various analytical techniques used for estimation of artemisinin. This review will reveal the facts about artemisinin which can be utilized to develop novel drug delivery system either in a combination or as alone for the wellbeing of the patients suffering from malaria.
Authors and Affiliations
Sanjay Sharma
The phylogenetic and evolutionary history of Kokobera virus
Objective: To estimate the genetic diversity of Kokobera virus, the date of origin and the spread among different viruses in the endemic regions of Australia. Methods: Two datasets were built. The first consisting of 29...
Epidemiological, prevention and control updates of yellow fever outbreak in Brazil
Yellow fever is an acute viral disease endemic to tropical countries, like Brazil, where, since the 1940s, has no significant documented outbreaks similar to that observed between 2016/2018 (2 045 confirmed cases and 677...
Worldwide risk factors in leishmaniasis
Recently, vector-borne parasitic diseases such as leishmaniasis have been emerged or reemerged in many geographical areas and resulted in global health and economic concerns that involve humans, domestic animals and wild...
The protection of Thymus vulgaris leaves alcoholic extract against hepatotoxicity of alcohol in rats
Objective: To investigate the protective effect of Thymus vulgaris (T. vulgaris) leaves 70% alcoholic extract against alcohol-mediate hepatotoxicity rats. Methods: The protective effect of T. vulgaris extract was investi...
Effects of aqueous extract of Notobasis syriaca on lipopolysaccharideinduced inflammation in rats
Objective: To investigate the effects of a dry aqueous extract of Notobasis syriaca (N. syriaca) on lipopolysaccharide (LPS)-induced inflammation in rats. Methods: Rats were fed the dried extract [500 mg/(kg•d)] for thre...