Pharmacological and Phytochemical Screenings of Ethanol Extract of Sterculia villosa Roxb.
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2013, Vol 2, Issue 1
Abstract
The antimicrobial, anti-inflammatory, membrane stabilization and anti-atherothrombosis activities of crude ethanol extract of leaves of Sterculia villosa Roxb. has been investigated. In antimicrobial assay by disc diffusion method, the extract showed mild to moderate antimicrobial activity with zone of inhibition ranging from 11-14 mm and 7-13 mm for test bacteria and fungi, respectively where the growth of Salmonella paratyphi and Pityrosporium ovale was strongly inhibited. In the in-vitro anti-atherothrombosis test, the crude extract exhibited 19.62% clot lysis as compared to the standard, streptokinase (81.53%). Moreover, the extract inhibited protein denaturation and haemolysis by 48% and 69.49% in the in-vitro anti-inflammatory and membrane stabilization test, respectively. Preliminary phytochemical screenings with the crude extract revealed the presence of alkaloids, glycosides, tannins, flavonoids, reducing sugars and gums.
Authors and Affiliations
Kamrun Nahar Tania| Department of Pharmacy, Faculty of Science and Engineering, Southern University Bangladesh, 739/A, Academic building-III, 22-Shahid Mirza Lane (E), Chittagong, Bangladesh., Md. Torequl Islam*| Department of Pharmacy, Faculty of Science and Engineering, Southern University Bangladesh, 739/A, Academic building-III, 22-Shahid Mirza Lane (E), Chittagong, Bangladesh., Ayesha Mahmood| Department of Pharmacy, Faculty of Science and Engineering, Southern University Bangladesh, 739/A, Academic building-III, 22-Shahid Mirza Lane (E), Chittagong, Bangladesh., Mohammed Ibrahim| Department of Pharmacy, Faculty of Science and Engineering, Southern University Bangladesh, 739/A, Academic building-III, 22-Shahid Mirza Lane (E), Chittagong, Bangladesh., M. Mohi Uddin Chowdhury| Department of Pharmacy, Faculty of Science and Engineering, Southern University Bangladesh, 739/A, Academic building-III, 22-Shahid Mirza Lane (E), Chittagong, Bangladesh., Md. Ruhul Kuddus| Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh., Mohammad A. Rashid| Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh.
Keywords
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