PHARMACOLOGICAL AND TOXICOLOGICAL EFFECTS OF HELIOTROPIUM UNDULATUM [H. BACCIFERUM] AND HELIOTROPIUM EUROPAEUM- A REVIEW
Journal Title: Indo American Journal of Pharmaceutical Sciences - Year 2018, Vol 5, Issue 4
Abstract
The phytochemical analysis of Heliotropium undulatum [Heliotropium bacciferum] revealed the presence of alkaloids, saponins, tannins, steroids, terpenoids, flavonoids, glycosides, and phenols. While, Heliotropium europaeum was shown to contain three major alkaloids: heliotrine N-oxide 0.08%, lasiocarpine 0.09% and lasiocarpine N-oxide 0.05%; and four minor alkaloids: heliotrine 0.02%, europine 0.02%, acetyllasiocarpine 0.03% and a novel alkaloid acetyllasiocarpine N-oxide 0.05%. Twenty six compounds were identified in the essential oil of Heliotropium europaeum. The previous pharmacological studies showed that these species possessed antioxidant, antimicrobial, anti-inflammatory and hapatoprotective effects. However, pyrrolizidine alkaloids were toxic for animals and human. This review was designed to highlight the chemical constituents, pharmacological and toxic effects of Heliotropium undulatum [Heliotropium bacciferum] and Heliotropium europaeum. Keywords: chemical constituents, pharmacology, toxicology,Heliotropium undulatum, Heliotropium bacciferum, Heliotropium europaeum
Authors and Affiliations
Ali Esmail Al-Snafi Ali Esmail Al-Snafi
Keywords
Related Articles
- EP ID EP277766
- DOI -
- Views 276
- Downloads 0
CHEMICAL CONSTITUENTS AND MEDICAL IMPORTANCE OF GALIUM APARINE - A REVIEW
The phytochemical screening of extracts of Galium aparine revealed that the plant contained phenols, tannins, alkaloids, anthraquinones, coumarins, iridoids asperuloside, alkanes, flavonoids and saponins. Previous pharma...
BIOCHEMICAL INVESTIGATION AND DEVELOPMENT OF HPLC METHOD FOR TACROLIMUS
The objective of this work was to develop a method for the quantification of tacrolimus in rabbit aqueous humor by UHPLC. UHPLC analysis was performed on a Waters Acquity UHPLC system (Milford, MA, USA). A 50 μL aliquot...
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF TRABECTEDIN IN BULK AND PARENTERAL DOSAGE FORM BY RP-HPLC
A new RP-HPLC method for the quantitative determination of Trabectedin was developed and validated as per ICH guidelines. The drugs were injected into Zorbax SB, C18,(150x4.6mm); 3.5µm column maintained at ambient temper...
AUTISM: A PSYCHOLOGICAL CHALLENGE FOR THE PATIENT AND THE FAMILY
Objectives: Research was aimed at the comparison of the self-concept in the sibling of the children having autism with the normal children siblings in the perspective of the psychological well-being of the mothers. Study...
A PROSPECTIVE RESEARCH ON THE FASCIO-CUTANEOUS FLAPS ROLE AS AN INTERVENTION OF THE COVERAGE OF SOFT TISSUE IN (TYPE 111 – B) OPEN TIBIAL FRACTURES
Object: The determination of the fascio-cutaneous flap role as the coverage of the soft tissue in open tibial fractures of type 111 – B as experienced by the professor of Mayo Hospital, Lahore. Material and Methods: Samp...