PHARMACOLOGICAL ASSESSMENT OF ANTIDIABETIC POTENTIAL OF HYDROALCOHOLIC EXTRACT OF CASSIA FISTULA LINN. IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2017, Vol 7, Issue 7
Abstract
Major public health problem “diabetes” is approaching epidemic proportions globally and increasing at alarming rate all over the world. The Medicinal plants of India plays important role in the management of diabetes as they possess potent activity against diabetes. The present study protocol is aimed to evaluate antidiabetic activities of hydroalcoholic extract of Cassia fistula pod in streptozotocin-induced diabetic rats. Diabetes was induced in the rats by single intraperitoneal administration of Streptozotocin (60 mg/kg b.wt.). C. fistula pod extract at three different doses (100, 200 and 500 mg/kg b.wt./day) were administered orally with for 30 days to diabetic rats. The results were compared with standard drug glibenclamide (5 mg/kg b.wt./day) treated rats. The results showed that streptozotocin treated diabetic control rats suffered with decrease in the body weight and glycogen content in the liver as well as significant increase in the blood glucose and glycosylated hemoglobin (HbA1c) levels as compared to normal control rats. Oral administration of C. fistula pod extract or glibenclamide to diabetic animals for 30 days increased body weight and hepatic glycogen content and significant reduction in the blood glucose and HbA1c levels and as compared to diabetic control rats. The present results and study showed that C. fistula pod possess significant antidiabetic activity.
Authors and Affiliations
Sapna Malviya
Keywords
Related Articles
- EP ID EP300631
- DOI -
- Views 58
- Downloads 0
SYNTHESIS AND ANTIMICROBIAL SCREENING OF SOME IMIDAZOLIDINE DERIVATIVES OF ISONICOTINAMIDE
New series of N (2-alkyl/aryl-5-oxo-imidazolidine-1-yl) isonicotinamide derivatives were synthesized by the reaction of Schiff base with amino acetic acid in the presence of 1:4 dioxane. Synthesized compounds were evalua...
DEVELOPMENT AND VALIDATION OF NEW SIMPLE, SENSITIVE AND VALIDATED UV-SPECTROPHOTOMETRIC AND RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF PARACETAMOL AND ETODOLAC IN MARKETED FORMULATION
A simple, precise and highly selective analytical method was developed for simultaneous estimation of Paracetamol and Etodolac in tablet formulation. Estimation was carried out by multicomponent mode of analysis at selec...
Management of Grahani Roga by Ayurveda principles and life style modification
Grahani is an ayurveda terms related to the seat of agni (digestive fire), which help in the metabolism and digestion of food. The ancient text of ayurveda described that ingestion, digestion, absorption and assimilation...
CRYSTAL ENGINEERING OF ANTIVIRAL AGENT EFAVIRENZ FOR SOLUBILITY ENHANCEMENT
In the current study, we attempted to improve the physicochemical properties of antiviral drug efavirenz through the cocrystal synthesis. The neat grinding performed to study the effect of coformer-fumaric acid (FA) on s...
Formulation and evaluation of polymeric nanoparticles of an antihypetensive drug for gastroretention
The aim of present study was to formulate and evaluate nanoparticles of carvedilol by using different hydrophilic polymers. Carvedilol was selected as a suitable drug for gastro- retentive nanoparticles due to its short...