PHARMACOLOGICAL ASSESSMENT OF ANTIDIABETIC POTENTIAL OF HYDROALCOHOLIC EXTRACT OF CASSIA FISTULA LINN. IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2017, Vol 7, Issue 7
Abstract
Major public health problem “diabetes” is approaching epidemic proportions globally and increasing at alarming rate all over the world. The Medicinal plants of India plays important role in the management of diabetes as they possess potent activity against diabetes. The present study protocol is aimed to evaluate antidiabetic activities of hydroalcoholic extract of Cassia fistula pod in streptozotocin-induced diabetic rats. Diabetes was induced in the rats by single intraperitoneal administration of Streptozotocin (60 mg/kg b.wt.). C. fistula pod extract at three different doses (100, 200 and 500 mg/kg b.wt./day) were administered orally with for 30 days to diabetic rats. The results were compared with standard drug glibenclamide (5 mg/kg b.wt./day) treated rats. The results showed that streptozotocin treated diabetic control rats suffered with decrease in the body weight and glycogen content in the liver as well as significant increase in the blood glucose and glycosylated hemoglobin (HbA1c) levels as compared to normal control rats. Oral administration of C. fistula pod extract or glibenclamide to diabetic animals for 30 days increased body weight and hepatic glycogen content and significant reduction in the blood glucose and HbA1c levels and as compared to diabetic control rats. The present results and study showed that C. fistula pod possess significant antidiabetic activity.
Authors and Affiliations
Sapna Malviya
Keywords
Related Articles
- EP ID EP300631
- DOI -
- Views 67
- Downloads 0
OBSTRUCTED PAN CAKE KIDNEY IN A CHILD MANAGED BY IMAGE GUIDED PERCUTANEOUS NEPHROSTOMY
Pancake kidney, also called pelvic fused kidney, lump or cake kidney, is a rare type of congenital renal fusion anomaly. It is characterized by the presence of a lobulated pelvic renal mass which has a dual parenchymatou...
CLOVE (SYZYGIUM AROMATICUM L.) AND THEIR EFFECT ON THE FORMATION OF HETEROCYCLIC AMINES
Heterocyclic amines (HCAs) are a group of toxic chemicals, play an important role in the etiology of human cancer which formed at high temperature during cooking meat and fish. Antioxidants have proved to inhibit the for...
Perception on generic drugs among general populace visiting a community pharmacy Jaipur, Rajasthan
Healthcare costs have been leading cause of poverty for many Indians. One of the solutions to this is to advocate generic drugs which are cheaper in comparison to brand name drugs. The government of India had made it man...
PREVALENCE OF POSTPARTUM DEPRESSION AND ITS ASSOCIATION WITH ANTENATAL DEPRESSION AMONGST WOMEN
Background: A prospective cross sectional study was designed to determine the prevalence rate of postpartum depression and its association with antenatal depression among women coming to the antenatal Clinic and birthing...
EFFECT OF NITROGEN SOURCE FOR THE BIOSYNTHESIS OF XYLANASE FROM ASPERGILLUS TAMARII
The main aim of the study is to enhance the biosynthesis of xylanse by incorporating nitrogen sources (both organic and inorganic). Recently, xylanases have expanded their use in many processing industries, such as pulp...