PHARMACOLOGICAL ASSESSMENT OF ANTIDIABETIC POTENTIAL OF HYDROALCOHOLIC EXTRACT OF CASSIA FISTULA LINN. IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2017, Vol 7, Issue 7
Abstract
Major public health problem “diabetes” is approaching epidemic proportions globally and increasing at alarming rate all over the world. The Medicinal plants of India plays important role in the management of diabetes as they possess potent activity against diabetes. The present study protocol is aimed to evaluate antidiabetic activities of hydroalcoholic extract of Cassia fistula pod in streptozotocin-induced diabetic rats. Diabetes was induced in the rats by single intraperitoneal administration of Streptozotocin (60 mg/kg b.wt.). C. fistula pod extract at three different doses (100, 200 and 500 mg/kg b.wt./day) were administered orally with for 30 days to diabetic rats. The results were compared with standard drug glibenclamide (5 mg/kg b.wt./day) treated rats. The results showed that streptozotocin treated diabetic control rats suffered with decrease in the body weight and glycogen content in the liver as well as significant increase in the blood glucose and glycosylated hemoglobin (HbA1c) levels as compared to normal control rats. Oral administration of C. fistula pod extract or glibenclamide to diabetic animals for 30 days increased body weight and hepatic glycogen content and significant reduction in the blood glucose and HbA1c levels and as compared to diabetic control rats. The present results and study showed that C. fistula pod possess significant antidiabetic activity.
Authors and Affiliations
Sapna Malviya
Keywords
Related Articles
- EP ID EP300631
- DOI -
- Views 73
- Downloads 0
PATTERN OF ANTIDIABETIC MEDICATION UTILIZATION IN PATIENTS ATTENDING DIABETIC CLINIC IN HIWOT FANA SPECIALIZED UNIVERSITY HOSPITAL, HARAR, ETHIOPIA
Purpose: Diabetes mellitus (DM) is a chronic condition that can have a major impact on life expectancy and quality of life, especially if undetected or poorly controlled. Glycaemic control and management of co-morbid con...
FORMULATION AND EVALUATION OF AN INJECTABLE SOLUTION AS A DOSAGE FORM
The present study will outline formulation and the evaluation methods of injectable dosage form. The various initial formulations of the developed and those are examined for drug release profile, bioavailability, and cli...
ADEQUACY OF THE CURRENT RECOMMENDED DOSAGE OF CIPROFLOXACIN IN PRETERM AND TERM NEONATES WITH SEPSIS
Objectives: To determine the percentage of neonates with sepsis, on treatment with standard recommended dose of intravenous ciprofloxacin, who had the serum ciprofloxacin Peak concentration: Minimum inhibitory concentra...
FORMULATION AND EVALUATION OF NOVEL FLOATING IN SITU GELLING SYSTEM OF MACROLIDE ANTIBIOTIC USING DIFFERENT GELLING POLYMERS
a
PREVALENCE OF POSTPARTUM DEPRESSION AND ITS ASSOCIATION WITH ANTENATAL DEPRESSION AMONGST WOMEN
Background: A prospective cross sectional study was designed to determine the prevalence rate of postpartum depression and its association with antenatal depression among women coming to the antenatal Clinic and birthing...