PHARMACOLOGICAL INVESTIGATION OF RANGER CAPSULE BY STUDYING ACUTE TOXICITY, IN VITRO ANTI OXIDANT PROPERTY AND IN VIVO ANTI-STRESS ACTIVITY
Journal Title: Journal of Biological and Scientific Opinion - Year 2014, Vol 2, Issue 1
Abstract
The stress is generally considered as the functional adaptation of the organism in order to cope up with changing and challenging environment. Exposure to stressful conditions is among the most common human experience. It has been reported that exposure to physical and mental stress situations can stimulate numerous pathways, leading to increased production of oxygen free radicals. In such situation, the antioxidant defense systems of body may become insufficient to scavenge all free radicals. In the present study, an attempt was made to evaluate acute toxicity of a herbo-mineral Ayurvedic formulation, Ranger capsule along with its in-vitro anti-oxidant property and in-vivo anti-stress activity. Acute toxicity study was carried out on wistar rats as per OECD Guidelines 423. For anti-stress activity forced swimming endurance test was carried out on wistar rats. During this study, Difference in rectal temperature and swimming time was noted. Blood samples were collected for estimation of serum cortisol and serum glucose level. The reduction potential of Ranger Capsule was determined by the in-vitro ferric reducing anti-oxidant power (FRAP) assay at various concentration. Study data revealed that Ranger Capsule didn’t produced any toxic effect even up to the dose level of 5000 mg/kg hence was proven as safe. The pre-treatment of Ranger Capsule prevented the fall of rectal temperature in highly significant manner and increased swimming time in comparison to stress control group. Ranger Capsule treated animals showed significant restriction in elevation of serum cortisol and serum glucose level as compared to stress control group. From the available results, it can be concluded that pre-treatment of Ranger Capsule is safe, capable to increase tolerance against non-specific stress in experimental animals and having significant anti-oxidant activity.
Authors and Affiliations
Hardik Soni , Divya Rana , Maitreyi Zaveri , Sonal Patel , Ghanashyam Patel
EXTRACTION OF COLOR PIGMENT AND DETERMINATION OF FLAVONOID CONTENT OF ANDONG LEAVES (CORDYLINE FRUTICOSA L.) SOURCE MAKASSAR CITY
Andong (Cordyline fructicosa L.) is the family of asparagaceae which knows as decorated plant, because the color is very interesting so that potentially as a source of natural pigments. This research was aimed to extract...
PHARMACOGNOSTIC, PHYSICOCHEMICAL AND PHYTOCHEMICAL INVESTIGATION OF TAGETES ERECTA LINN FLOWERS (ASTERACEAE)
Standardization is used in herbal medicine to try to make extracts of the same herbs as similar to each other. It is used to describe all measures which are taken during the manufacturing process and quality control lead...
PSYCHOLOGICAL ASPECTS OF CARDIOVASCULAR DISEASES AND THE HOLISTIC APPROACH OF AYURVEDA
Psychosomatic approach is a unique concept stated in Ayurveda which is the base for understanding the health and diseased state of an individual. Chikitsa is also based on this concept. Cardiovascular disorders are the m...
CONCEPT OF HAIR AND ITS CARE IN AYURVEDA
Hair (Kesha) is a crown of head and barometer of one’s beauty. Now-a-days because of faulty and speedy life style people have not time and also don’t know about proper way of hair care and will be met different types of...
CLINICAL EVALUATION OF MAJOON YAHYA BIN KHALID AND LOCAL APPLICATION OF ROGHAN DARCHINI IN MANAGEMENT OF PRIMARY KNEE OSTEOARTHRITIS
Primary knee osteoarthritis is an extremely common cause of disability of lower extremities which results due to breakdown and destruction of joint tissues. The present study was designed to evaluate the efficacy of Majo...