Pharmacology of “atypicality” of antipsychotic drugs: status and perspective
Journal Title: Archives of Psychiatry and Psychotherapy - Year 2010, Vol 12, Issue 4
Abstract
Summary “Atypical” antipsychotics are antagonists at serotonin 5-HT2A and dopamine D2 receptors. However, their effects on negative symptoms and cognitive deficits remain modest and they disrupt metabolic function. Recent drugs, such as aripiprazole, perospirone, bifeprunox, lurasidone and cariprazine act as D2 receptor antagonists (or partial agonists) combined with 5-HT1A receptor activation. The latter prevents extrapyramidal symptoms, favors prefrontal cortex dopaminergic neurotransmission, has a beneficial influence on mood and opposes cognitive deficits. Further, recent drugs exhibit little interaction at sites associated with side-effects such as metabolic disorders or autonomic disturbance. However, these drugs differ in their balance of 5-HT1A/D2 receptor properties and this is likely to translate to distinct therapeutic profiles.
Authors and Affiliations
Adrian Newman-Tancredi, Mark Kleven
Keywords
Related Articles
- EP ID EP144929
- DOI -
- Views 77
- Downloads 0
Paralinguistic communication in the therapeutic relationship
The author, on the basis of literature and his professional therapeutic experience, describes the meaning of vocal signals in diagnosing patients’ problems and improving communication during a therapeutic dialogue. In th...
Anxiety and depression in spouses of males diagnosed with alcohol dependence: a comparative study
Aim of the study In this study, we aim to compare the proportion of anxiety and depression among spouses of males with alcohol use disorder with spouses of males without alcohol use disorder. Subject or material and met...
The neutral stimuli detection deficits in delusion-prone individuals
Aim. The aim of the study was to investigate whether the delusion-prone individuals tend to select relevant information among distractors in order to examine whether the occurrence of overt delusions could be preceded by...
Recovery from psychiatric disability and personal autonomy
Several subjective and objective indicators mark recovery from psychiatric disabilities. One of these markers, frequently mentioned in the literature, is autonomous decision-making of a disabled person. The purpose of th...
The Nuclear Family Functioning Scale (NFFS): Polish adaptation of the American model and analysis of its psychometric properties
Aim of the study The aim of the study was to develop and validate the Polish version of the Family Genogram Interview (FGI), an instrument designed to measure emotional processess conceptualized by Bowen family systems t...