Pharmacotherapy Patterns of Diabetic Foot Ulcer Patients at Hayatabad Medical Complex, Peshawar, Pakistan: A Prospective Study
Journal Title: Healthcraft Frontiers - Year 2024, Vol 2, Issue 3
Abstract
A two-month prospective study conducted at Hayatabad Medical Complex (HMC) Peshawar, Pakistan. In this study the pharmacotherapy patterns and drug-drug interaction (DDI) incidences were analyzed among 150 diabetic patients, of whom 50 presented with diabetic foot ulcer (DFU). Significant deviations from World Health Organization (WHO) core prescribing indicators were observed, particularly in the areas of polypharmacy and generic prescribing practices. The majority of DFU patients were from urban regions, with sedentary lifestyle factors identified as prominent contributors to DFU development. A higher incidence of DFU was noted among male patients with type 2 diabetes mellitus (T2DM) compared to female patients. Age distribution analysis revealed that patient ages ranged from 8 to 85 years, with 68% falling within the 41-60 age bracket, while only 2% were under 20 years of age. Among the all 391 pharmacotherapeutic agents prescribed, injectable medications constituted the majority (47.82%). Analysis of DDIs showed that 39.1% of prescribed medications were associated with drug interactions, with 72% of these classified as major interactions. The most frequently observed major DDIs involved combinations such as aspirin with Ramipril and Pregabalin with Losartan. These findings highlight the necessity for clinical pharmacists to review prescribing regimens to mitigate the risk of severe DDIs. The high prevalence of diabetes and DFU in this patient cohort is closely associated with lifestyle factors, insufficient health education, and lack of physical activity. These findings underline the urgent need for preventative strategies, including lifestyle modifications and public health education. Further investigation is recommended to enhance understanding of DFU risk factors and to develop improved prognostic and preventive frameworks.
Authors and Affiliations
farooq khan, abid ullah
Keywords
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- EP ID EP752324
- DOI 10.56578/hf020301
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