Phenotypes of the [i]Drosophila melanogaster [/i]caused by dysfunction of dystrophin and dystroglycan
Journal Title: Biopolymers and cell (Біополімери і клітина, Биополимеры и клетка) - Year 2011, Vol 27, Issue 6
Abstract
Dystrophin and dystroglycan, the main components of the dystrophin-glycoprotein complex, are essential for normal vital activity of the [i]D. melanogaster[/i] during ontogenesis. Mutations in the genes, which encode these proteins, cause different phenotypes, among manifestations of which we noticed characters similar to those observed at human muscular dystrophy. Furthermore, several other phenotypes have beendescribed; their study will shed light on our understanding the development of different pathologies. In addition, it gives an opportunity to reveal new components of the dystrophin-glycoprotein complex as well as new regulatory proteins, which influence the functions of this complex. Thus, based on the [i]D. melanogaster[/i], an appropriate model has been developed to study human myopathies.
Authors and Affiliations
V Rishko , N Holub , Ya. Chernyk
Keywords
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