PHENYTOIN INDUCED TOXIC EPIDERMAL NECROLYSIS; A CASE REPORT
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2017, Vol 6, Issue 3
Abstract
Several drugs are at high risk of causing Toxic Epidermal Necrolysis (TEN) including Anti-convulsants such as phenytoin, carbamazepine and phenobarbital. Other drugs include antimicrobials like sulfonamides followed by Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and anti-gout drugs.1 We are presenting a case of 60 year old female patient with Phenytoin induced TEN. Who had a history of cranial surgery 3 weeks prior to admission and prescribed with discharge medications of phenytoin, diclofenac and dexamethasone. After 3 weeks of treatment, patient has developed oral and genital erosions with itchy vesicles and bullae all over the body and admitted to tertiary care hospital with complaints of burning sensation on chest and pedal edema and hematuria for 3 days. Phenytoin induced TEN was suspected and was admitted from causality. The patient was managed aggressively with steroids, higher antibiotics and creams (over the lesion), nutritional supplement was taken care of and palliative care was given. The patient expired due to septic shock and multiple organ dysfunctions with metabolic acidosis after 8 day of admission. This case highlights the importance of Phenytoin possibly causing TEN. Government of India and Regulatory Authorities should create awareness among practitioners to report all the ADRs to concerned ADR Monitoring Centers. Keywords: Phenytoin induced TEN, Septic shock, metabolic acidosis.
Authors and Affiliations
Merphin Philip Thomas
Keywords
Related Articles
- EP ID EP417426
- DOI -
- Views 153
- Downloads 0
Characteristics of liposome used for drug delivery system
Liposome as a drug delivery system is emerges as a one of the potential in pharmaceutical industries. The properties of nano-medicines such as release from dosage forms at specific sites as well as drug circulation and a...
Evaluation of α-glucosidase inhibition and antioxidant potential of Acacia modesta root bark
The α-glucosidase inhibition and antioxidant potential of dichloromethane and methanolic extracts of Acacia modesta root bark were evaluated to provide basis for isolation and structure elucidation of bioactive compounds...
Study of drug utilization pattern in the department of obstetrics and gynecology
Objective: To assess the drug utilization pattern of drugs in the department of obstetrics and gynecology at tertiary care Hospital. Materials and Methods: A prospective observational study on drug utilization pattern wa...
IDENTIFICATION OF FIFTH SEROTYPE OF DENGUE VIRUS AND VACCINATION: A REVIEW
Dengue fever is a re-emerging public health problem with two-fifths of the world population being at risk of infection. Till now, dengue fever was believed to be caused by four different serotypes. The fifth variant DENV...
EVALUATION OF MECHANICAL PLAQUE REMOVAL EFFECTIVENESS OFTOOTHBRUSH AND ITS MODIFICATIONS IN INTELLECTUALLY DISABLEDCHILDREN.
Background: Disability is an umbrella term that includes aproblem in the body single-valued function or structure. Disabled children reveal a high prevalence of gingivitis and also show non-compliance towards brushing. H...