PHILADELPHIA CHROMOSOME POSITIVE CHRONIC MYELOGENOUS LEUKEMIA IN CHILDHOOD:A RARE CASE REPORT
Journal Title: Era's Journal of Medical Research - Year 2017, Vol 4, Issue 1
Abstract
CML is a clonal hematopoietic stem cell disorder. As per WHO classification, CML is included in Myeloproliferative disorder. Adult type - CML is rare in childhood constituting about 3% of childhood leukaemia. We have reported such a case in a 7yr old male child. Peripheral blood smear and bone marrow revealed features of chronic myeloproliferative disorder and cytogenetic analysis has proved Ph chromosome positivity. We report one such case of Philadelphia positive CML in a 7 year old male patient with chief complaints of fever on & off since 4-5 months and sense of abdominal fullness since 1 month, on examination pallor was found with mild hepatomegaly and moderate splenomegaly. The clinical differential diagnosis was malaria, storage disorder or tropical splenomegaly. Though biological behaviour and prognosis are identical to that of adult type, we are reporting this case because of its extremely uncommon incidence.
Authors and Affiliations
Kshama Tiwari, Sharique Ahmad, Kshitij Tewari, Amrisha Jaiswal, Sania Zahra Rizvi, Syed Riaz Mehdi
Keywords
Related Articles
- EP ID EP282526
- DOI 10.24041/ejmr2017.8
- Views 120
- Downloads 0
THYROID STIMULATORY HORMONE (TSH) REFERENCE RANGES IN THE NORMAL PREGNANT WOMEN OF LUCKNOW
Maternal hypothyroidism is known to be associated with adverse perinatal outcomes. This study was done to evaluate the normal reference range of TSH in pregnant women. 483 pregnant women on their first visit to Obstetric...
Association of Angiotensin-Converting Enzyme (ACE) and Glutathione S-Transferase (GST) Gene Polymorphisms with Diabetic Nephropathy
Diabetic nephropathy accounts for the most serious microvascular complication of diabetes mellitus. It is suggested that the prevalence of diabetic nephropathy will continue to increase in future pretense a major challen...
CYTOLOGY OF ADRENAL LESIONS
Cystic and solid lesions in the adrenal glands commonly present as mass lesions and have varied etiology as infectious diseases, benign eysts, adrenal neoplastic lesions and metastasis. Smaller sized and nonfunctional sm...
EFFECT OF ETHANOLIC SEED EXTRACT OF CITRUS LANATUS (WATERMELON) ON IMMUNOREACTIVITY OF HIPPOCAMPAL NEUROFILAMENT OF ADULT WISTAR RATS
Neurofilaments are major protein constituents of the brain, and play important roles in trafficking of molecules between neurons. An experimental study on thetotal protein content and immunoreactivity of neurofilament pr...
THE STUDY OF NUTRIENT FORAMEN OF BONES OF ARM AND FOREARM IN ADULTS
The variation in presence of number of nutrient foramen is important in long bones as nutrient foramen gives passage for entrance of nutrient arteries in to the bone. The present study was conducted on total 114 dry huma...