PHILADELPHIA CHROMOSOME POSITIVE CHRONIC MYELOGENOUS LEUKEMIA IN CHILDHOOD:A RARE CASE REPORT
Journal Title: Era's Journal of Medical Research - Year 2017, Vol 4, Issue 1
Abstract
CML is a clonal hematopoietic stem cell disorder. As per WHO classification, CML is included in Myeloproliferative disorder. Adult type - CML is rare in childhood constituting about 3% of childhood leukaemia. We have reported such a case in a 7yr old male child. Peripheral blood smear and bone marrow revealed features of chronic myeloproliferative disorder and cytogenetic analysis has proved Ph chromosome positivity. We report one such case of Philadelphia positive CML in a 7 year old male patient with chief complaints of fever on & off since 4-5 months and sense of abdominal fullness since 1 month, on examination pallor was found with mild hepatomegaly and moderate splenomegaly. The clinical differential diagnosis was malaria, storage disorder or tropical splenomegaly. Though biological behaviour and prognosis are identical to that of adult type, we are reporting this case because of its extremely uncommon incidence.
Authors and Affiliations
Kshama Tiwari, Sharique Ahmad, Kshitij Tewari, Amrisha Jaiswal, Sania Zahra Rizvi, Syed Riaz Mehdi
Keywords
Related Articles
- EP ID EP282526
- DOI 10.24041/ejmr2017.8
- Views 141
- Downloads 0
Association of Angiotensin-Converting Enzyme (ACE) and Glutathione S-Transferase (GST) Gene Polymorphisms with Diabetic Nephropathy
Diabetic nephropathy accounts for the most serious microvascular complication of diabetes mellitus. It is suggested that the prevalence of diabetic nephropathy will continue to increase in future pretense a major challen...
SYNCHRONOUS CLEAR CELL RENAL CELL CARCINOMA AND TUBULOCYSTIC RENAL CELL CARCINOMA
Tubulocystic renal cell carcinoma (TCRCC) is a recently described rare subtype of RCC. To best of our knowledge less than 70 cases have been reported till date. The concurrent papillary RCC (PRCC) and TCRCC has been docu...
STUDY OF ETIOLOGY OF HEPATOMEGALY WITH SPECIAL EMPHASIS ON NON ALCOHOLIC FATTY LIVER DISEASE AT A TEACHING HOSPITAL
Hepatomegaly may be a presenting sign or symptom of the patient's illness or it may be an incidental finding in patients being examined for various other reasons At present, many patients are diagnosed with liver disease...
PATHOLOGY OF OBESITY
Prevalence of obesity worldwide is on an increase at an alarming rate with USAalone showing a 37.5% increase in obese individuals. Obesity is defined by the basal metabolic rate of the individual however off-late waist i...
USES AND PROSPECTS OF NANOTECHNOLOGY IN FOOD & NUTRITION: A REVIEW
Use of nanotechnology in food science to increase/alter nutritive value and shelf life of food has provided lot of dimensions in research to meet out the need of food for globally growing population. Fortification of foo...