PHOTOCHEMICAL REACTIONS OF FORMYLMETHYLFLAVIN AND RIBOFLAVIN
Journal Title: Baqai Journal of Health Sciences - Year 2015, Vol 18, Issue 2
Abstract
Formylmethylflavin (FMF) is a major intermediate product in the aerobic and anaerobic photolysis of riboflavin (RF) and is highly sensitive to light and hydrolysis. It is more sensitive to light as compared to RF. FMF is further degraded into lumichrome (LC), carboxymethylflavin (CMF) in acidic medium, and LC, CMF and lumiflavin (LF) in alkaline medium. When FMF is exposed to light it is degraded in to LC and LF via a photoreduction and CMF through photooxidation pathways. In aerobic and anaerobic conditions, RF when exposed to light is excited to singlet state (1RF) and from singlet to triplet state (3RF). This is followed by the conversion of 3RF into a semiquinone radical (RFH) and this radical further disproportionate to form an oxidized RF and a cyclic intermediate, which is further oxidized to FMF and degradation products (LC, LF, CMF).
Authors and Affiliations
Tania Mirza, Zubair Anwar, Samina Shiekh, Iqbal Ahmad
COMPARATIVE ANALYSIS OF BLOOD GROUPING IN HEALTHY BLOOD DONOR USING GEL CARD TECHNIQUE AND TUBE METHOD
Blood grouping is a vital test in pre-transfusion testing. Both tube and gel agglutination assays are used for ABO grouping. The main object of this study was to compare ABO grouping and D typing on tube and gel agglutin...
PEPTIC ULCER DISEASE: PATHOGENESIS AND DIAGNOSIS
Helicobacter pylori is a gram-negative bacteria which forms colonies in gastric mucosa and is responsible for peptic ulcer diseases (PUDs). The present review deals with the strategies employed in the diagnosis of H. pyl...
DEVELOPMENT, VALIDATION AND KINETIC APPLICATION OF SPECTROMETRIC METHODS FOR THE ANALYSIS OF ASPIRIN, SALICYLIC ACID, AND CAFFEINE AS SINGLE-COMPONENT AND IN MIXTURES
Aspirin (ASA) and aspirin-caffeine dosage forms are widely used as analgesic drugs. In the present study specific stability-indicating two- and three-component spectrometric methods have been developed for the assay of A...
IMPROVEMENT IN EDUCATION THROUGH NEUROLOGICAL PRINCIPLES
No Abstract Available
ORAL CONTROLLED RELEASE MATRIX FORMULATION DESIGN AND THEIR RATE CONTROLLING FACTORS
The trend of formulation development of controlled release (CR) matrix drug delivery system has been increased to many folds during the last few years. Such CR dosage forms are now considered to be more effective than co...