PHOTOCHEMICAL REACTIONS OF FORMYLMETHYLFLAVIN AND RIBOFLAVIN
Journal Title: Baqai Journal of Health Sciences - Year 2015, Vol 18, Issue 2
Abstract
Formylmethylflavin (FMF) is a major intermediate product in the aerobic and anaerobic photolysis of riboflavin (RF) and is highly sensitive to light and hydrolysis. It is more sensitive to light as compared to RF. FMF is further degraded into lumichrome (LC), carboxymethylflavin (CMF) in acidic medium, and LC, CMF and lumiflavin (LF) in alkaline medium. When FMF is exposed to light it is degraded in to LC and LF via a photoreduction and CMF through photooxidation pathways. In aerobic and anaerobic conditions, RF when exposed to light is excited to singlet state (1RF) and from singlet to triplet state (3RF). This is followed by the conversion of 3RF into a semiquinone radical (RFH) and this radical further disproportionate to form an oxidized RF and a cyclic intermediate, which is further oxidized to FMF and degradation products (LC, LF, CMF).
Authors and Affiliations
Tania Mirza, Zubair Anwar, Samina Shiekh, Iqbal Ahmad
Keywords
Related Articles
- EP ID EP198706
- DOI -
- Views 170
- Downloads 0
TOTAL PARENTERAL NUTRITION (TPN): ROLE OF RIBOFLAVIN (VITAMIN B2) AND CYANOCOBALAMIN (VITAMIN B12)
Total parenteral nutrition (TPN) replaces and maintains essential nutrients in patients in whom oral or tube feedings are contraindicated or inadequate. A nutritional assessment must be carried out before initiating TPN...
STUDY ON CAMPHOR-FREE NATURAL TOPICAL MEDICINE FOR UPPER RESPIRATORY TRACT INFECTIONS IN CHILDREN
Upper respiratory tract infections (URTI) are the most common acute illnesses that are often of viral origin. Cough and chest congestion are the common symptoms of this disease. Children are prescribed with drugs that ar...
PLAGUE — THE HIDDEN OLD NEMESIS
Plague is a disease of rodents carried to man by fleas and is non-existent in Pakistan. It represents a typical example of the evolution of human disease from an infection, originally confined to wild animals. Due to the...
RUBBER DAM PLACEMENT: WHY MAJORITY OF SENIOR DENTISTS PRACTICING IN HA'IL, SAUDI ARABIA IGNORES IT?
Isolation of operating site from saliva and other oral fluids prior to commencing a restorative or endodontic procedure via rubber dam is considered as standard healthcare protocol. Numerous studies have been globally co...
CORRELATION BETWEEN UMBILICAL CORD BLOOD VOLUME WITH GESTATIONAL AGE AND BIRTH WEIGHT: A BASELINE FOR CORD BLOOD BANKS IN PAKISTAN
Placental vessels contain one-third of newborn blood volume termed as umbilical cord blood (UCB). It is an enriched product with many benefits but unfortunately, it is usually discarded as waste. Since the identification...