Phylogenetic Considerations in the Evolutionary Development of Aminoglycoside Resistance Genes in Pathogenic Bacteria
Journal Title: Annual Research & Review in Biology - Year 2016, Vol 9, Issue 2
Abstract
This study revisits antibiotic resistance as a source of evolutionary development in pathogenic bacteria. By taking a molecular phylogenetic approach to this inquiry, I seek to find homologous correlations in antimicrobial resistance gene families across a broad spectrum of bacteria, as to identify the possible acquisition of those genes through divergent events in evolutionary context. In order to test this, I examine the various degrees of genetic similarity in two antimicrobial resistance genomic datasets, namely aadA1 & aadA2 aminoglycoside resistance genes, among bacteria that occur in a multitude of environments. Moreover, the results from phylogenetic analysis suggests that pathogenic antibiotic resistance for aadA1 & aadA2 aminoglycoside resistance genes may have been acquired through evolutionary events with a common ancestor of a soil-dwelling bacterium.
Authors and Affiliations
Tommy Rodriguez
Keywords
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- EP ID EP350953
- DOI 10.9734/ARRB/2016/22895
- Views 118
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