PHYSICOCHEMICAL CHARACTERIZATION OF AMORPHOUS SOLID DISPERSION OF KETOPROFEN–POLYVINYLPYRROLIDONE K-30
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 2
Abstract
Objective: The aim of the current study was to prepare an amorphous solid dispersion of ketoprofen in polymer PVP K-30 by solvent co-evaporation technique and to characterize the physicochemical properties. Methods: An amorphous solid dispersion of ketoprofen, a water insoluble non-steroidal anti- inflammatory drug with polyvinyl pyrrolidone K-30, were prepared by solvent co-evaporation method at drug to polymer ratios 1:1, 1:3, 1:5 and 1:9 (w/w). Physicochemical properties of the solid drug were evaluated by X-ray powder diffractometry (XRPD), differential thermal analysis (DTA) and scanning electron microscopy (SEM). Dissolution studies were conducted according to the USP paddle method.Results: The X-ray powder diffraction and differential thermal analysis showed that ketoprofen was transformed from a crystalline phase to an amorphous state, as showed by disappearance of its characteristic of diffraction peaks and an endothermic peak. SEM Microphoto of amorphous solid dispersion showed homogeneous size and morphology. In addition, ketoprofen in amorphous solid dispersion showed better dissolution rate compared to crystalline drugs. The dissolution efficiency (DE) of ketoprofen from its amorphous solid dispersion increased with an increasing ratio of polymer.Conclusion: The study has shown that dispersions of ketoprofen into water-soluble polymer PVP K-30 formed an amorphous ketoprofen in solid dispersion system. All amorphous solid dispersion of ketoprofen in PVP K-30 prepared by solvent co-evaporation demonstrated a significant improvement in dissolution rate of ketoprofen compared to pure ketoprofen.Â
Authors and Affiliations
Salman . , Ardiansyah . , Ellyza Nasrul, Harrizul Rivai, Elfi Sahlan Ben, Erizal Zaini
Keywords
Related Articles
- EP ID EP579065
- DOI -
- Views 70
- Downloads 0
ESTIMATION OF ANTIOXIDANT AND ANTIBACTERIAL ACTIVITY OF CRUDE EXTRACTS OF THEVETIA PERUVIANA (PERS.) K. SCHUM.
Objective: The aim of this investigation was to estimate antioxidant and antibacterial activity of different crude extracts of Thevetia peruviana (Pers.) K. Schum.Methods: Aqueous and alcoholic crude extracts of differen...
CAUSE-EFFECT RELATIONS AND OPTIMIZATION OF TABLET CONTAINING EUCOMMIA ULMOIDES AND GARDENIA JASMINOIDES SPRAY-DRIED EXTRACTS
Objective: The E. ulmoides and G. jasminoides (EG) tablets containing 67 mg E. ulmoides spray-dried extract (ESE) and 173 mg G. jasminoides spray-dried extract (GSE) were prepared by employing the direct compression meth...
CANDESARTAN REVERSES MEMORY DEFICIT CAUSED BY COLCHICINE INDUCED CHOLINERGIC DYSFUNCTION AND OXIDATIVE STRESS
Objective: We sought to investigate the protective activity of candesartan against memory impairment, oxidative stress and cholinergic dysfunction induced by activation of the central renin-angiotensin system.Methods: Ma...
FORMULATION, OPTIMIZATION AND EVALUATION OF FLOATING TABLETS CLARITHROMYCIN
Objective: The present aim of this study was to formulate, optimize and evaluation of floating tablets of Clarithromycin.Methods: Floating tablets of Clarithromycin were formulated using polymer HPMC K15M with sodium bic...
HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECTS OF ANNONA MURICATA L. LEAF ETHANOL EXTRACT
Objective: The aim of this study was to investigate hypoglycemic and hypolipidemic effects of Annona muricata leaf ethanol extract. This study also investigated phytochemical analysis of the extract and improvement in th...