Physiological Dynamics of Platelets’ Activity in Aged Rats
Journal Title: Annual Research & Review in Biology - Year 2017, Vol 18, Issue 2
Abstract
The process of aging inevitably touches the system of hemostasis and leads very often to the development of thrombophilia. Platelets are an important component of hemostasis as they mostly determine its activity on the whole. It’s very interesting to estimate the dynamics of platelet activity in rats as they are important objects of laboratory investigations in the period of their bodies’ evident aging – at the age between 18 and 30 months of life. The aim of the study is to establish the peculiarities of age-specific dynamics of platelet activity in aged rats. There were examined 95 healthy Wister male-rats, including 32 rats at the age of 18 months, 29 rats at the age of 24 months and 34 rats at the age of 30 months. The control group was composed of 27 healthy male-rats of Wistar line at the age of 6 months. We applied biochemical, hematological and statistical methods of investigation. Between 18-30 months of life the rats were noted to have rise of acylhydroperoxides’ content in plasma on 19.9%, thiobarbituric acid-active products – on 18.9% and lowering of plasma antioxidant activity on 23.8%. Between 18-30 months of life healthy rats were found to have gradual acceleration of platelet aggregation (platelet aggregation with ADP at the age of 18 months was equal to 38.4±0.12s, at the age of 30 months – 33.1±0.16s), content increase of platelets’ active forms in their blood (disco-echinocytes at the age of 18 months – 14.0±0.18%, at the age of 30 months – 17.5±0.17%) and number increase of their freely circulating aggregates (small aggregates at the age of 18 months – 3.5±0.09, at the age of 30 months – 7.2±0.13 on 100 freely lying platelets). Found increase of platelet activity in rats contributes greatly to their rising with age morbid aggravation, increase of their bodies’ sensitivity to negative impacts of environmental factors and promotes the realization of hereditary predisposition to different pathology. Received results can be useful for future researches connected with formation aspects of age-specific thrombophilia and can be taken into account at estimation of different variants of life’s experimental prolongation.
Authors and Affiliations
I. N. Medvedev
Keywords
Related Articles
- EP ID EP313468
- DOI 10.9734/ARRB/2017/36821
- Views 78
- Downloads 0
Isolation of Parasites from Black Tiger Prawn; Peneaus monodon from Isaka River, Okirika Local Government Area, Rivers State, Nigeria
Aims: To determine the parasitic fauna, site-specificity of the parasites in the host and the parasite load in relation to length, weight and sex of P. mondon. Study Design: The study is a survey using prawns from Isaka...
Epidemiology of Human Leptospirosis in the Central Region of Veracruz, Mexico
Aims: To epidemiologically characterize patients confirmed as cases of leptospirosis in Central Veracruz, Mexico based on official records. Study Design: Descriptive retrospective study. Place and Duration of Study: Sani...
Protective Potential of Grape Seed Proanthocyandins Extract against Glivec (Imatinib Mesylate) Induced Liver Toxicity and Oxidative Stress in Male Rats
Objectives: Glivec (Imatinib mesylate) an antineoplastic chemotherapeutic agent used in the treatment of many types of cancer. The current study examines the hepatoprotective potential of grape seed proanthocyandins extr...
Effect of Peste des petits ruminants Vaccination on Clinico-haematological Parameters of West African Dwarf Sheep Experimentally Infected with Trypanosoma congolense
Aim: The research was conducted to determine the clinico-haematological parameters and impacts of Peste des petits ruminants (PPR) vaccination and trypanocidal treatment in Trypanosoma congolense infected West African Dw...
Variation of Mineral Micronutrient Elements in Robusta Coffee (Coffea canephora Pierre ex A. Froehner) As Measured by Energy Dispersive X -Ray Fluorescence
Aim: Robusta coffee growing countries of the world such as Uganda, have experienced a decline in market prices since 2002 due to changed consumer preferences for other beverages. In Uganda, where Robusta coffee is the ma...