Physiological effect of Natural Penicillin Extract on Cassava Peel Media by Penicillium chrysogenum PCL501 on E.coli Infected Wistar Rats
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2017, Vol 7, Issue 4
Abstract
ABSTRACT:- Some physiological effect of natural penicillin extract produced on cassava peel media by Penicillium chrysogenum PCL501 on E.coli infected Wistar rats were evaluated. Fermentation of P. chrysogenum PCL501 with cassava peels – an agro-waste- produced natural antibiotics. In vitro antibiotic activity of cassava peels culture extract was tested against two clinical bacterial isolates, namely, Bacillus subtilis, and Escherichia coli. The culture extract and standard drug (commercial Benzyl Penicillin) inhibited the growth B. subtilis and E. coli. Antibiotic activity of the culture extract was comparable with that of the standard drug. In vivo antibiotic action on Wistar Wistar rats infected with E. coli showed that the penicillin produced on cassava peel was potent as its administration leads to the recovery of the infected animals. Evaluation of biochemical indices of E. coli infected Wistar rats and treatment with extract confirms that the extract is a potent antibiotic. The haematological evaluation showed a significant decrease (p<0.05) in platelet count in animals administered with both the extract and reference drug. Cassava peels are indicated as a suitable and cheap carbon source for the production of penicillin by P. chrysogenum PCL501.
Authors and Affiliations
Onyegeme-Okerenta, B. M, Ebuehi O. A. T.
Keywords
Related Articles
- EP ID EP253357
- DOI -
- Views 104
- Downloads 0
Reproductive Biology of an Endangered Coldwater Fish Golden Mahseer, Tor Putitora (Ham.) From Anji Mahseer Hatchery Reasi (J&K)
The Golden Mahseer (Tor Putitora) forms an important fishery resource in coldwater areas of Himalaya, India. The study covers reproductive factors of T. putitora from Anji Mahseer Hatchery Reasi, Jammu & Kash...
Spectral and Biological investigations of Nd(III) Juglonates
Abstract: Metal chelates of Nd(III) with Lawsone , juglone, Phthiocol and Plumbagin are synthesized and are characterized with the help of elemental analysis, Infrared spectroscopy, UV visible spectrosco and TGA. Morphol...
UPLCMS Method Development and Validation of Tablet Dosage form Containing Glimepiride, Metformin and Pioglitazone Using Internal Standard
A simple, rapid, sensitive and specific Ultra performance liquid chromatography-tandem mass spectrometry method was developed and validated for simultaneous estimation and validation of tablet dosage form contain...
[b] A STUDY OF MORBIDITY PROFILE OF GERIATRIC POPULATION IN THE FIELD PRACTICE AREA OF RURAL HEALTH TRAINING CENTRE, PAITHAN OF GOVT. MEDICAL[/b] [b]COLLEGE, AURANGABAD[/b]
Utilization of Potato peel and Curd whey as the Agro industrial substrates for Biosurfactant production using Pseudomonas aeruginosa PBS29
This study elicited the utilization of the cheapest agro-industrial waste as the major substrate for Biosurfactant production. The fermentation medium was formulated by supplementing the substrates, Homogenized Potato pe...