PHYSIOLOGICAL IMPORTANCE OF OSTEOPONTIN
Journal Title: Indian journal of applied basic medical sciences - Year 2014, Vol 16, Issue 22
Abstract
ABSTRACT Osteopontin a recently discovered ubiquitous glycoprotein secreted from various cells of the body. It has been found to anchor to bone cells to mineralize the bone matrix. As per some researches its uropontin form has shown to reduce growth of calcium crystals in the mice renal system; yet others suggest opposite role of this molecule in- vitro. Its modified form has great functional role in immune system by acting as a modulator in variety of manners other than regulating apoptosis. It plays important role in immigration of neutrophil and migration and degranulation of the mast cells. Its role in VSMC growth has well been demonstrated by various in-vivo and in- vitro experiments. Its versatile importance in respiratory physiology, cancer metastasis has been proved but many more physiological and clinical functions are still hidden which researchers are trying to find out for the treatment modality in near future.
Authors and Affiliations
PUJA DULLO
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