Physiologically Based Absorption Modelling to Predict the Impact of Drug Properties on Pharmacokinetics of Bitopertin
Journal Title: The AAPS Journal - Year 2014, Vol 16, Issue 5
Abstract
The online version of this article (doi:10.1208/s12248-014-9639-y) contains supplementary material, which is available to authorized users.
Authors and Affiliations
Neil Parrott, Dominik Hainzl, Emmanuel Scheubel, Siegfried Krimmer, Christophe Boetsch, Elena Guerini, Meret Martin-Facklam
Keywords
Related Articles
- EP ID EP681673
- DOI 10.1208/s12248-014-9639-y
- Views 89
- Downloads 0
Overview of the Proton-coupled MCT (SLC16A) Family of Transporters: Characterization, Function and Role in the Transport of the Drug of Abuse γ-Hydroxybutyric Acid
The transport of monocarboxylates, such as lactate and pyruvate, is mediated by the SLC16A family of proton-linked membrane transport proteins known as monocarboxylate transporters (MCTs). Fourteen MCT-related genes have...
Systematic Verification of Bioanalytical Similarity Between a Biosimilar and a Reference Biotherapeutic: Committee Recommendations for the Development and Validation of a Single Ligand-Binding Assay to Support Pharmacokinetic Assessments
The online version of this article (doi:10.1208/s12248-014-9669-5) contains supplementary material, which is available to authorized users.
R4 Regulator of G Protein Signaling (RGS) Proteins in Inflammation and Immunity
G protein-coupled receptors (GPCRs) have important functions in both innate and adaptive immunity, with the capacity to bridge interactions between the two arms of the host responses to pathogens through direct recogniti...
Novel Molecular Targets of Azadirachta indica Associated with Inhibition of Tumor Growth in Prostate Cancer
The online version of this article (doi:10.1208/s12248-011-9279-4) contains supplementary material, which is available to authorized users.
Mu opioid receptor regulation and opiate responsiveness
Opiate drugs such as morphine are well known for their ability to produce potent analgesia as well as such unwanted side effects as tolerance, physical dependence, respiratory suppression and constipation. Opiates act at...