Phytochemical and Anti-microbial Study of Seventy Percent Methanol Leaf Extract of Terminalia microptera against Selected Pathogenic Bacteria
Journal Title: Journal of Advances in Medical and Pharmaceutical Sciences - Year 2016, Vol 9, Issue 1
Abstract
The phytochemical and antimicrobial activity of Terminalia microptera leaf methanol (70%) crude extract was determined against some selected pathogenic microorganisms using the qualitative phytochemical, tube dilution and agar well diffusion methods respectively. The results of the phytochemical analysis shows that all the phytochemicals analysed for were present; these include alkaloid, flavonoids, saponins, cardiac glycosides, anthraquinons, sterols, phlobatanins and terpenes. All organisms screened were found to be sensitive to the extract at all the concentrations. Klebsiella pneumoniae was more susceptible to the extract with mean zones of inhibitions of 24.33±0.88, 29.33±0.33 and 33.33±0.88 for 20, 30 and 40 mg/ml respectively followed closely by Streptococcus pyogenese and Salmonella typhi with mean zones of inhibitions of 17.67±0.88, 25.00±0.58 & 28.67±0.88 and 17.00±0.58, 18.33±0.67 & 21.33±0.67 respectively while Micrococcus luteus, Pseudomonas aeruginosa and Streptococcus mutans sensitivity were seen to be on the lower side with mean zones of inhibitions of 15.67±0.33, 18.67±0.88 and 17.33±0.67 respectively at 40 mg/ml. In the same vein, Klebsiella pneumoniae had the lowest minimum inhibitory concentration of 1.25 mg/ml and minimum bactericidal concentration of 10 mg/ml i.e, it is more susceptible to the plant extract while Pseudomonas aeruginosa, Streptococcus mutans, Salmonella typhi and Salmonella paratyphi C were more resistant to the extract with MIC of 10 mg/ml. The result of this study shows that extracts from Terminalia microptera had antimicrobial activity against the test organisms and therefore can be used to develop drugs that can be used to treat infections caused by these organisms.
Authors and Affiliations
Daniel Augustine Innalegwu, Ewansiha Joel Uyi, Amuda Oladuni Amuda, Nathaniel Vivian
Keywords
Related Articles
- EP ID EP328456
- DOI 10.9734/JAMPS/2016/27370
- Views 83
- Downloads 0
Self-Medication with Antibiotics amongst Civil Servants in Uyo, Southern Nigeria
Background: Self-medication with antibiotics constitute a major form of irrational use of medicines and can cause significant adverse effects such as resistant microorganisms, treatment failure, drug toxicity, increase i...
Anxiolytic Effect of Aqueous Root Extract of Citrus aurantium in Wistar Albino Rats
Anxiety is a very common mental disorder among neurological disorders. Citrus aurantium decoction has been used to treat anxiety- like behaviour, by traditional medicine practitioners in Nasarawa State, Nigeria. The aim...
Evaluation of CNS Depressant, Antidiarrheal and Antipyretic Activities of Ethanolic Leaf Extract of Calophyllum inophyllum L. on Swiss Albino Mice
Objective: The main objective of the present study was to evaluate the CNS depressant, antidiarrheal and antipyretic activities of ethanolic leaf extract of Calophyllum inophyllum L. Methods: In the present study CNS dep...
Potency and Properties of Hydrazide Compounds That Inhibit the Growth of Mycobacterium tuberculosis
Aims: To examine the properties of hydrazide compounds shown to inhibit Mycobacterium tuberculosis. To identify properties that affect efficiency of bacterial inhibition. Study Design: Utilizing data from previous studie...
Prescribing Errors in Nigeria’s Healthcare System; Exploration towards Promoting Rational Prescribing for Improved Patient Care
Rational prescribing is vital to achieving rational drug use but limited studies exist on the prescription practices, causes, and types of prescription error in developing countries. Prescription error is one of the lead...