Phytochemical and toxicity evaluation of Phaleria macrocarpa (Scheff.) Boerl by MCF-7 cell line and brine shrimp lethality bioassay
Journal Title: Journal of Coastal Life Medicine - Year 2016, Vol 4, Issue 1
Abstract
Objective: To evaluate the cytotoxicity of Phaleria macrocarpa fruits extracts. Methods: The cytotoxicity test was carried out by in vitro MCF-7 cell line and in vivo brine shrimp lethality bioassay. Results: The preliminary phytochemical test showed the presence of alkaloids, carbohydrate, glycosides, saponin, terpene, steroids, phenols and flavonoids. The MTT-assay results showed that the highest percentage of cell viability was 106.23% at concentration of 1.25 µL and the lowest percentage was 13.04% at concentration of 10 µL. Conclusions: The MTT-assay and brine shrimp lethality bioassay results showed that the extract was non-toxic and it would be consumable as a herbal remedy.
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- EP ID EP240073
- DOI 10.12980/jclm.4.2016j5-194
- Views 136
- Downloads 0
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