Phytochemical, Antimicrobial Potential and Antifungal Activities Stem Bark Extract of Boswellia Ovalifoliolata
Journal Title: Archives of Organic and Inorganic Chemical Sciences - Year 2018, Vol 1, Issue 5
Abstract
This study was carried out with an objective to investigate the antibacterial and antifungal potentials of Stem bark of Boswellia ovalifoliolata (BO). The aim of the study is to assess the antimicrobial activity and to determine the zone of inhibition of extracts on some bacterial and fungal strains. In the present study, the microbial activity of ethanolic extracts of stem bark of Boswellia ovalifoliolata. (Endemic medicinal plant) was evaluated for potential antimicrobial activity against medically important bacterial and fungal strains. The antimicrobial activity was determined in the extracts using agar disc diffusion method. The antibacterial and antifungal activities of extracts (5, 25, 50, 100, 250μg/ml) of Boswellia ovalifoliolata. Were tested against two Gram-positive Staphylococcus aureus, Streptococcus pyogenes two Gram-negative-Escherichia coli, Pseudomonas aeruginosa human pathogenic bacteria. Three fungal strains Aspergillus niger, Aspergillus clavatus, Candida albicans. Zone of inhibition of extracts were compared with that of different standards like ampicillin, ciprofloxacin, norfloxacin, and chloramphenicol for antibacterial activity and nystatin and griseofulvin for antifungal activity. The results showed that the remarkable inhibition of the bacterial growth was shown against the tested organisms. The phytochemical analyses of the plants were carried out. The microbial activity of the Boswellia ovalifoliolata was due to the presence of various secondary metabolites. Hence, these plants can be used to discover bioactive natural products that may serve as leads in the development of new pharmaceuticals research activities. Antibiotics are one of our most important weapons in fighting bacterial infections and have vastly improved the quality of human life since their introduction. However, over the past few decades, these health benefits are under threat as many commonly used antibiotics have become less and less effective against certain illnesses, not only because many of them produce toxic reactions, but also due to emergence of drug-resistant bacteria. It is essential to investigate new drugs. Drugs derived from natural sources play a significant role in the prevention and treatment of human diseases. In many developing countries, traditional medicine is one of the primary healthcare systems [1,2]. Herbs are widely used in the traditional medicine and their curative potentials are well documented [3]. About 61% of new drugs developed between 1981 and 2002 were based on natural products and they have been very successful especially in the areas of infectious disease and controlling cancer [4]. Recent trends, however, show that the discovery rate of active novel chemical entities is declining [5]. Natural products of higher plants may give a new source of antimicrobial agents with possibly novel mechanisms of action [6,7]. The effects of plant extracts on bacteria have been studied by a very large number of researchers in different parts of the world[8]. Much work has been done on ethnomedicinal plants in Ethiopia[9]. Plants are rich in a wide variety of secondary metabolites such as tannins, terpenoids, alkaloids, flavonoids, glycosides, etc., which have been found in vitro to have antimicrobial properties [10,11].
Authors and Affiliations
Teklit Gebregiorgis, Birhanu nigussie
Keywords
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- EP ID EP600440
- DOI 10.32474/AOICS.2018.01.000122
- Views 65
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