Phytochemical Constitutents and Antidiabetic Property of Cola nitida Seeds on Alloxan-Induced Diabetes Mellitus in Rats
Journal Title: Journal of Pharmaceutical Research International - Year 2014, Vol 4, Issue 23
Abstract
The seeds of Cola nitida were investigated for their anti-diabetic properties. The extracts were obtained by maceration in cold water. Alloxan was used to induce diabetes mellitus (DM) in the rats at 180mg/kg body weight and diabetes was confirmed after 48 hours. The Phytochemical analyses of the plants showed the presence of tannin, flavonoid, terpernoid, cardiac-gylcoside, and alkaloids. Anthraquinone and saponin were observed to be absent. Cola nitida was also observed to cause a reduction in blood glucose level from 599±0.667mg/dl (diabetic control) to 170±0.577mg/dl (extract treated group). The extract showed a significant (P<0.05) decrease of blood glucose level in alloxan induced diabetic rats. Cola nitida aqueous extract showed a higher level of potency when compared to a known anti-diabetic drug (Glanil).
Authors and Affiliations
Iliemene Uju Dorathy, Shekins O. Okere, Eze Ejike Daniel, Liman Labaran Mubarak
Hepatoprotective Activity of Macrotyloma uniflorum (Lam.) Verdc. Seeds Extracts Against Paracetamol Induced Hepatotoxicity in Wistar Albino Rats
Background: Macrotyloma uniflorum (Horse gram) seeds are used in Ayurvedic medicine for treating numerous health disorders including rheumatism, worm, conjunctivitis and piles. The seeds were boiled with water and used a...
Superporous Hydrogel Composites of Acrylamide Using Starch-silicone Dioxide Coprecipitate as Composite Agent
Aim: Present study includes the development and evaluation of superporous hydrogel composites of acrylamide using starch silicone dioxide coprecipitate (SSC) as composite agent. Methodology: Gas blowing method was used f...
Synthesis of Some Novel Semicarbazone and Thiosemicarbazone Derivatives of Isatin as Possible Biologically Active Agents
Aims: The development of new beneficial agents is one of the crucial aims in medicinal chemistry. Isatin is considered as a vital class of bioactive compounds exhibiting different biological activities. A series of nine...
Antidepressant-like Activity of Celastrus paniculatus Seed Oil in Mice Subjected to Chronic Unpredictable Mild Stress
Aims: The present study was done to evaluate the antidepressant-like effect of Celastrus paniculatus seed oil in Swiss young albino mice subjected to chronic unpredictable mild stress. Study Design: Prospective. Place an...
Study and Evaluation of Medication Errors in Medicine and Orthopedic Wards of a Tertiary Care Hospital
Aims: The main aim of the present study was to detect and evaluate the incidence, types, factors and severity of medication errors in the medicine and orthopedic wards of a tertiary care hospital. Study Design: This was...